124 228

Cited 0 times in

The impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function: an observational study.

Authors
 Hyunwook Kim  ;  Shin-Wook Kang  ;  Tae-Hyun Yoo  ;  Myoung Soo Kim  ;  Soon Il Kim  ;  Yu Seun Kim  ;  Kyu Hun Choi 
Citation
 BMC NEPHROLOGY, Vol.13 : 22, 2012 
Journal Title
 BMC NEPHROLOGY 
Issue Date
2012
MeSH
Adolescent ; Adult ; Analysis of Variance ; Confidence Intervals ; Female ; Glomerular Filtration Rate* ; Humans ; Kidney Transplantation/physiology* ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Postoperative Period ; Preoperative Period ; Renal Replacement Therapy/adverse effects ; Republic of Korea ; Seasons ; Serum Albumin/metabolism ; Sex Factors ; Sunlight ; Vitamin D/analogs & derivatives* ; Vitamin D/blood ; Vitamin D Deficiency/complications* ; Vitamin D Deficiency/etiology ; Young Adult
Keywords
Kidney Transplantation ; Graft Function ; Serum Albumin Level ; Acute Rejection Episode ; Early Graft Function
Abstract
BACKGROUND: In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D level on subsequent graft function has not been explored. Therefore, this study was undertaken to examine the effect of serum vitamin D level at the time of kidney transplantation (KT) on subsequent graft function. METHODS: We analyzed 106 patients who underwent KT and for whom 25-hydroxy vitamin D (25-OHD) levels were measured during hospitalization prior to transplantation. We measured estimated glomerular filtration rates (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula at baseline and at six-month intervals up to 36 months after KT. RESULTS: 38.7% of the patients were diagnosed with 25-OHD deficiency defined as less than 10 ng/mL. Recipient gender (female vs. male, odds ratio [OR] 3.30, 95% CI 1.33-8.21, P=0.010), serum albumin level (per 1 mg/dl increase, OR 0.35, 95% CI 0.13-0.98, P=0.047), and predominant renal replacement therapy modality before KT (P<0.001) were found to be independent pretransplant risk factors for 25-OHD deficiency by multivariate logistic regression analysis. Subsequent repeated measures analysis of covariance revealed that 25-OHD level had the only significant main effect on eGFR during the 36-month follow-up period [F (1, 88)=12.07, P=0.001]. CONCLUSIONS: Pretransplant 25-OHD deficiency was significantly associated with a lower post-transplant eGFR, suggesting that 25-OHD may play an important role in maintaining graft function after KT.
Files in This Item:
T201201967.pdf Download
DOI
22533967
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89791
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse