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Body fluid identification in forensics.

Authors
 Ja Hyun An  ;  Kyoung-Jin Shin  ;  Woo Ick Yang  ;  Hwan Young Lee 
Citation
 BMB REPORTS, Vol.45(10) : 545-553, 2012 
Journal Title
BMB REPORTS
ISSN
 1976-6696 
Issue Date
2012
Keywords
Alternate light source ; Body fluid identification ; Catalytic test ; Chemical test ; DNA methylation ; Forensic ; Immunological test ; miRNA ; mRNA
Abstract
Determination of the type and origin of the body fluids found at a crime scene can give important insights into crime scene reconstruction by supporting a link between sample donors and actual criminal acts. For more than a century, numerous types of body fluid identification methods have been developed, such as chemical tests, immunological tests, protein catalytic activity tests, spectroscopic methods and microscopy. However, these conventional body fluid identification methods are mostly presumptive, and are carried out for only one body fluid at a time. Therefore, the use of a molecular genetics-based approach using RNA profiling or DNA methylation detection has been recently proposed to supplant conventional body fluid identification methods. Several RNA markers and tDMRs (tissue-specific differentially methylated regions) which are specific to forensically relevant body fluids have been identified, and their specificities and sensitivities have been tested using various samples. In this review, we provide an overview of the present knowledge and the most recent developments in forensic body fluid identification and discuss its possible practical application to forensic casework.
Files in This Item:
T201203752.pdf Download
DOI
10.5483/BMBRep.2012.45.10.206
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89770
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