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Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy

Authors
 Kuewhan Jang ; Kilho Eom ; Taeyun Kwon ; Woo-Jae Kim ; Eunseon Kim ; Jaemoon Yang ; Seungjoo Haam ; Jae-Hee Han ; Gyudo Lee 
Citation
 Biochip Journal, Vol.6(4) : 396~403, 2012 
Journal Title
 Biochip Journal 
ISSN
 1976-0280 
Issue Date
2012
Abstract
Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based photothermal agents using pyrene-based PEGylation of SWNTs. FT-IR and/or H-NMR spectroscopies have validated the PEGylation of SWNTs, and it is shown that water-soluble SWNTs are able to generate heat under near-infrared (NIR) irradiation of 5W/cm2. Moreover, it is found that our pyrene-based PEGylated SWNTs exhibit the fluorescence characteristic under the excitation wavelength of 340 nm. Our study sheds light on the pyrenyl PEGylated SWNTs as photothermal agents and/or fluorescence contrast agents for the future applications in molecular therapeutics.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89716
DOI
10.1007/s13206-012-6412-0
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007/s13206-012-6412-0
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