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Serum glycated albumin predicts the progression of carotid arterial atherosclerosis.

 Sun Ok Song  ;  Kwang Joon Kim  ;  Byung-Wan Lee  ;  Eun Seok Kang  ;  Bong Soo Cha  ;  Hyun Chul Lee 
 Atherosclerosis, Vol.225(2) : 450-455, 2012 
Journal Title
Issue Date
Aged ; Biomarkers/blood ; Blood Pressure ; Carotid Artery Diseases/blood* ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Chi-Square Distribution ; Cholesterol/blood ; Diabetes Mellitus, Type 2/blood* ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Angiopathies/blood* ; Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/physiopathology ; Disease Progression ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Logistic Models ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Serum Albumin/metabolism* ; Time Factors ; Triglycerides/blood
Glycated albumin ; Type 2 diabetes ; Carotid intima media ; Thickness ; GA/A1c ratio
INTRODUCTION: We investigated the association between the ratio of serum glycated albumin (GA) levels to hyperglycemic levels (GA/A1c ratio) and the progression of carotid artery atherosclerosis. METHODS: For this retrospective longitudinal study we recruited patients who had undergone carotid IMT measurement twice and been tested consecutively for both A1c and GA levels every 3 or 6 months. The subjects were classified into two groups based on non-progression (group I) and progression (group II) of carotid IMT. Mean values of A1c and GA and the GA/A1c ratio were compared between groups. RESULTS: Of the 218 subjects (122 men and 96 women), group II (n=77) showed significantly higher baseline systolic BP, eGFR, GA, GA/A1c ratio, and progression of carotid IMT (Δ IMT) than group I (n = 141). The mean A1c level tended to be higher in group II than in group I (p = 0.054). By Spearman's correlation test, baseline diastolic BP, total cholesterol, triglyceride, GA, and GA/A1c were significantly associated with Δ IMT in group II but not in group I. In multivariate regression analysis, serum level of GA and GA/HbA1c ratio predicted progression of IMT after adjustment for other risk factors in both models applied. CONCLUSION: We suggest that glycated albumin is not only a useful glycemic index but also might be an atherogenic protein in the development of diabetic atherosclerosis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Song, Sun Ok(송선옥)
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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