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Serum glycated albumin predicts the progression of carotid arterial atherosclerosis.
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 송선옥 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2014-12-19T16:30:56Z | - |
dc.date.available | 2014-12-19T16:30:56Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89675 | - |
dc.description.abstract | INTRODUCTION: We investigated the association between the ratio of serum glycated albumin (GA) levels to hyperglycemic levels (GA/A1c ratio) and the progression of carotid artery atherosclerosis. METHODS: For this retrospective longitudinal study we recruited patients who had undergone carotid IMT measurement twice and been tested consecutively for both A1c and GA levels every 3 or 6 months. The subjects were classified into two groups based on non-progression (group I) and progression (group II) of carotid IMT. Mean values of A1c and GA and the GA/A1c ratio were compared between groups. RESULTS: Of the 218 subjects (122 men and 96 women), group II (n=77) showed significantly higher baseline systolic BP, eGFR, GA, GA/A1c ratio, and progression of carotid IMT (Δ IMT) than group I (n = 141). The mean A1c level tended to be higher in group II than in group I (p = 0.054). By Spearman's correlation test, baseline diastolic BP, total cholesterol, triglyceride, GA, and GA/A1c were significantly associated with Δ IMT in group II but not in group I. In multivariate regression analysis, serum level of GA and GA/HbA1c ratio predicted progression of IMT after adjustment for other risk factors in both models applied. CONCLUSION: We suggest that glycated albumin is not only a useful glycemic index but also might be an atherogenic protein in the development of diabetic atherosclerosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Carotid Artery Diseases/blood* | - |
dc.subject.MESH | Carotid Artery Diseases/diagnosis | - |
dc.subject.MESH | Carotid Artery Diseases/physiopathology | - |
dc.subject.MESH | Carotid Intima-Media Thickness | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Cholesterol/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/blood* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/diagnosis | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/physiopathology | - |
dc.subject.MESH | Diabetic Angiopathies/blood* | - |
dc.subject.MESH | Diabetic Angiopathies/diagnosis | - |
dc.subject.MESH | Diabetic Angiopathies/physiopathology | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycated Hemoglobin A/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Serum Albumin/metabolism* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Serum glycated albumin predicts the progression of carotid arterial atherosclerosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sun Ok Song | - |
dc.contributor.googleauthor | Kwang Joon Kim | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.identifier.doi | 23040867 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02029 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 23040867 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915012006181 | - |
dc.subject.keyword | Glycated albumin | - |
dc.subject.keyword | Type 2 diabetes | - |
dc.subject.keyword | Carotid intima media | - |
dc.subject.keyword | Thickness | - |
dc.subject.keyword | GA/A1c ratio | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Song, Sun Ok | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Song, Sun Ok | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.citation.volume | 225 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 450 | - |
dc.citation.endPage | 455 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.225(2) : 450-455, 2012 | - |
dc.identifier.rimsid | 31846 | - |
dc.type.rims | ART | - |
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