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Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes.

Authors
 Jung Hyun Kwaka  ;  Jean Kyung Paika  ;  Hye In Kimb  ;  Oh Yoen Kimc  ;  Dong Yeob Shind  ;  Hye-Jin Kime  ;  Jin Hee Leef  ;  Jong Ho Leea 
Citation
 ATHEROSCLEROSIS, Vol.224(2) : 457-464, 2012 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2012
MeSH
Biomarkers/blood ; Biomarkers/urine ; Blood Glucose/metabolism* ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/diet therapy* ; Diabetes Mellitus, Type 2/physiopathology ; Digestion ; Dinoprost/analogs & derivatives ; Dinoprost/urine ; Double-Blind Method ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology* ; Female ; Humans ; Hydrolysis ; Hyperemia/physiopathology ; Insulin/blood ; Insulin Resistance ; Male ; Malondialdehyde/blood ; Manometry ; Middle Aged ; Nitric Oxide/blood ; Oryza/genetics ; Oryza/metabolism* ; Oxidative Stress* ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism* ; Postprandial Period ; Prediabetic State/blood ; Prediabetic State/diagnosis ; Prediabetic State/diet therapy* ; Prediabetic State/physiopathology ; Republic of Korea ; Starch/metabolism* ; Superoxide Dismutase/blood ; Time Factors ; Treatment Outcome
Keywords
Rice containing resistant starch ; Endothelial function ; Postprandial glucose ; Oxidative stress ; Prediabetes ; Newly diagnosed type 2 diabetes
Abstract
OBJECTIVE: We aimed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function. METHODS: Patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes (n = 90) were randomly assigned to either a group ingesting rice containing 6.51 g resistant starch daily or a control rice group for 4-weeks. We assessed fasting and postprandial levels of glucose and insulin, oxidative stress markers and endothelial function using reactive hyperemia peripheral arterial tonometry (RH-PAT). RESULTS: The diet containing rice with resistant starch reduced fasting insulin and insulin resistance, postprandial glucose (P = 0.010) and insulin levels at 30 min, and glucose and insulin areas under the response curve after the standard meal. Rice with resistant starch also decreased urinary 8-epi-PGF(2α) and plasma malondialdehyde (MDA) and increased the RH-PAT index (P < 0.001) and total nitric oxide (NO). Postprandial changes in glucose at 60 and 120 min and areas under the glucose response curve, MDA, RH-PAT, and total NO of the test group differed significantly from those in the control even after adjusting for baseline values. Overall, changes in the RH-PAT index correlated positively with changes in total NO (r = 0.336, P = 0.003) and superoxide dismutase activity (r = 0.381, P = 0.001) and negatively with changes in MDA (r = -0.358, P = 0.002) and 8-epi-PGF(2α). CONCLUSIONS: In patients with IFG, IGT or newly diagnosed type 2 diabetes, 4-weeks of dietary treatment with rice containing resistant starch was associated with improved endothelial function with reduction of postprandial glucose and oxidative stress compared with control.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915012005485
DOI
22954674
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89674
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