0 537

Cited 0 times in

Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes.

DC Field Value Language
dc.contributor.author신동엽-
dc.date.accessioned2014-12-19T16:30:54Z-
dc.date.available2014-12-19T16:30:54Z-
dc.date.issued2012-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89674-
dc.description.abstractOBJECTIVE: We aimed to evaluate whether 4-week of dietary treatment with rice containing resistant starch reduces blood glucose and oxidative stress as well as improves endothelial function. METHODS: Patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly diagnosed type 2 diabetes (n = 90) were randomly assigned to either a group ingesting rice containing 6.51 g resistant starch daily or a control rice group for 4-weeks. We assessed fasting and postprandial levels of glucose and insulin, oxidative stress markers and endothelial function using reactive hyperemia peripheral arterial tonometry (RH-PAT). RESULTS: The diet containing rice with resistant starch reduced fasting insulin and insulin resistance, postprandial glucose (P = 0.010) and insulin levels at 30 min, and glucose and insulin areas under the response curve after the standard meal. Rice with resistant starch also decreased urinary 8-epi-PGF(2α) and plasma malondialdehyde (MDA) and increased the RH-PAT index (P < 0.001) and total nitric oxide (NO). Postprandial changes in glucose at 60 and 120 min and areas under the glucose response curve, MDA, RH-PAT, and total NO of the test group differed significantly from those in the control even after adjusting for baseline values. Overall, changes in the RH-PAT index correlated positively with changes in total NO (r = 0.336, P = 0.003) and superoxide dismutase activity (r = 0.381, P = 0.001) and negatively with changes in MDA (r = -0.358, P = 0.002) and 8-epi-PGF(2α). CONCLUSIONS: In patients with IFG, IGT or newly diagnosed type 2 diabetes, 4-weeks of dietary treatment with rice containing resistant starch was associated with improved endothelial function with reduction of postprandial glucose and oxidative stress compared with control.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiomarkers/urine-
dc.subject.MESHBlood Glucose/metabolism*-
dc.subject.MESHDiabetes Mellitus, Type 2/blood-
dc.subject.MESHDiabetes Mellitus, Type 2/diagnosis-
dc.subject.MESHDiabetes Mellitus, Type 2/diet therapy*-
dc.subject.MESHDiabetes Mellitus, Type 2/physiopathology-
dc.subject.MESHDigestion-
dc.subject.MESHDinoprost/analogs & derivatives-
dc.subject.MESHDinoprost/urine-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHEndothelium, Vascular/metabolism-
dc.subject.MESHEndothelium, Vascular/physiopathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHydrolysis-
dc.subject.MESHHyperemia/physiopathology-
dc.subject.MESHInsulin/blood-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHMale-
dc.subject.MESHMalondialdehyde/blood-
dc.subject.MESHManometry-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNitric Oxide/blood-
dc.subject.MESHOryza/genetics-
dc.subject.MESHOryza/metabolism*-
dc.subject.MESHOxidative Stress*-
dc.subject.MESHPlants, Genetically Modified/genetics-
dc.subject.MESHPlants, Genetically Modified/metabolism*-
dc.subject.MESHPostprandial Period-
dc.subject.MESHPrediabetic State/blood-
dc.subject.MESHPrediabetic State/diagnosis-
dc.subject.MESHPrediabetic State/diet therapy*-
dc.subject.MESHPrediabetic State/physiopathology-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHStarch/metabolism*-
dc.subject.MESHSuperoxide Dismutase/blood-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleDietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Hyun Kwaka-
dc.contributor.googleauthorJean Kyung Paika-
dc.contributor.googleauthorHye In Kimb-
dc.contributor.googleauthorOh Yoen Kimc-
dc.contributor.googleauthorDong Yeob Shind-
dc.contributor.googleauthorHye-Jin Kime-
dc.contributor.googleauthorJin Hee Leef-
dc.contributor.googleauthorJong Ho Leea-
dc.identifier.doi22954674-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02093-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid22954674-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0021915012005485-
dc.subject.keywordRice containing resistant starch-
dc.subject.keywordEndothelial function-
dc.subject.keywordPostprandial glucose-
dc.subject.keywordOxidative stress-
dc.subject.keywordPrediabetes-
dc.subject.keywordNewly diagnosed type 2 diabetes-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.citation.volume224-
dc.citation.number2-
dc.citation.startPage457-
dc.citation.endPage464-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.224(2) : 457-464, 2012-
dc.identifier.rimsid31845-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.