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Pseudomonas aeruginosa bacteriophage PA1Ø requires type IV pili for infection and shows broad bactericidal and biofilm removal activities

Authors
 Shukho Kim  ;  Marzia Rahman  ;  Sung Yong Seol  ;  Sang Sun Yoon  ;  Jungmin Kim 
Citation
 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol.78(17) : 6380-6385, 2012 
Journal Title
 APPLIED AND ENVIRONMENTAL MICROBIOLOGY 
ISSN
 0099-2240 
Issue Date
2012
MeSH
Bacteriolysis* ; Biofilms/growth & development* ; Biological Therapy/methods ; Fimbriae, Bacterial/physiology* ; Pseudomonas Infections/therapy ; Pseudomonas Phages/growth & development ; Pseudomonas Phages/physiology* ; Pseudomonas aeruginosa/physiology* ; Pseudomonas aeruginosa/virology* ; Virus Internalization*
Keywords
Bacteriolysis* ; Biofilms/growth & development* ; Biological Therapy/methods ; Fimbriae, Bacterial/physiology* ; Pseudomonas Infections/therapy ; Pseudomonas Phages/growth & development ; Pseudomonas Phages/physiology* ; Pseudomonas aeruginosa/physiology* ; Pseudomonas aeruginosa/virology* ; Virus Internalization*
Abstract
We isolated a new lytic Pseudomonas aeruginosa phage that requires type IV pili for infection. PA1Ø has a broad bactericidal spectrum, covering Gram-positive and Gram-negative bacteria, and can eradicate biofilm cells. PA1Ø may be developed as a therapeutic agent for biofilm-related mixed infections with P. aeruginosa and Staphylococcus aureus.
Files in This Item:
T201202422.pdf Download
DOI
22752161
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89594
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