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Surgical complications in gastric cancer patients preoperatively treated with chemotherapy: their risk factors and clinical relevance

Authors
 Ji Yeong An  ;  Kyung Min Kim  ;  Yoo Min Kim  ;  Jae-Ho Cheong  ;  Woo Jin Hyung  ;  Sung Hoon Noh 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.19(8) : 2452-2458, 2012 
Journal Title
 ANNALS OF SURGICAL ONCOLOGY 
ISSN
 1068-9265 
Issue Date
2012
MeSH
Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Follow-Up Studies ; Gastrectomy/mortality* ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Postoperative Complications* ; Preoperative Care ; Prognosis ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Survival Rate
Keywords
Gastric Cancer ; Postoperative Complication ; Gastric Cancer Patient ; Surgical Complication ; Preoperative Chemotherapy
Abstract
BACKGROUND: This study was designed to identify risk factors and oncological value for the development of postoperative complications after gastrectomy in gastric cancer patients with preoperative chemotherapy. METHODS: A total of 123 gastric cancer patients who underwent gastrectomy after chemotherapy were enrolled in this study. The incidence, type, risk factors, and prognostic value of surgical complications were evaluated. RESULTS: The postoperative complication rate was 29.3% and mortality rate was 1.6%. The development of postoperative complications was associated with operation time (>200 min) and transfusion during surgery. The resection extent, preoperative chemotherapy cycles and regimens, tumor stage, and patients' nutritional status were not predictive factors for the development of surgical complications. In the multivariate analysis, operation time was an independent risk factor for the development of postoperative complications (odds ratio, 3.813; P = 0.011). The median follow-up after surgery was 19 months. The 3-year, disease-free survival was 57.1% in patients without complications and 25.7% in patients with complications (P = 0.004). Multivariable analysis demonstrated postoperative complications were a significant prognostic factor for disease-free survival (hazard ratio, 2.676; P = 0.024). CONCLUSIONS: The incidence of surgical complications was high in gastric cancer patients who received preoperative chemotherapy. Long operation time was a risk factor for surgical complications, and the development of postoperative complication was predictive of patients' prognoses
Full Text
http://link.springer.com/article/10.1245%2Fs10434-012-2267-9
DOI
22395984
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoo Min(김유민)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Cheong, Jae Ho(정재호) ORCID logo https://orcid.org/0000-0002-1703-1781
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89555
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