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Anaphylactic transfusion reaction in a patient with anhaptoglobinemia: the first case in Korea

Authors
 Hyunsoo Kim  ;  Jonghyeon Choi  ;  Kyoung Un Park  ;  Hyon-Suk Kim  ;  Yoo Hong Min  ;  Moon Jung Kim  ;  Hyun Ok Kim 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.32(4) : 304-306, 2012 
Journal Title
 ANNALS OF LABORATORY MEDICINE 
ISSN
 2234-3806 
Issue Date
2012
MeSH
Alleles ; Anaphylaxis/etiology* ; Antineoplastic Agents/therapeutic use ; Female ; Gene Deletion ; Haptoglobins/genetics* ; Haptoglobins/immunology ; Humans ; Isoantibodies/immunology ; Leukemia, Promyelocytic, Acute/complications ; Leukemia, Promyelocytic, Acute/diagnosis* ; Leukemia, Promyelocytic, Acute/drug therapy ; Middle Aged ; Phenotype ; Platelet Transfusion/adverse effects* ; Recurrence ; Republic of Korea ; Thrombocytopenia/complications ; Thrombocytopenia/diagnosis
Keywords
Anaphylaxis ; Haptoglobin ; Platelet transfusion
Abstract
Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the first case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
Files in This Item:
T201203641.pdf Download
DOI
22779074
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89516
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