115 248

Cited 0 times in

CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations

Authors
 Yoonmi Seok  ;  Juwon Kim  ;  Jong Rak Choi  ;  Yu Ri Kim  ;  Seo-Jin Park  ;  Sue Jung Kim  ;  Jaewoo song  ;  Kyung-A Lee 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.32(1) : 95-98, 2012 
Journal Title
 ANNALS OF LABORATORY MEDICINE 
ISSN
 2234-3806 
Issue Date
2012
MeSH
Aged, 80 and over ; Bone Marrow/immunology ; Bone Marrow/metabolism ; CD5 Antigens/metabolism* ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 3 ; Gene Rearrangement ; Humans ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lymphoma, Mantle-Cell/diagnosis* ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/immunology ; Male ; Oncogene Proteins, Fusion/genetics* ; Proto-Oncogene Proteins c-myc/genetics* ; Translocation, Genetic
Keywords
CCND1 ; MYC ; Mantle cell lymphoma
Abstract
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
Files in This Item:
T201203090.pdf Download
DOI
22259787
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sue Jeong(김수정)
Kim, Yu Ri(김유리) ORCID logo https://orcid.org/0000-0001-5505-0142
Kim, Ju Won(김주원)
Park, Seo Jin(박서진)
Seok, Yoon Mi(석윤미)
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89511
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse