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CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations

Authors
 Yoonmi Seok  ;  Juwon Kim  ;  Jong Rak Choi  ;  Yu Ri Kim  ;  Seo-Jin Park  ;  Sue Jung Kim  ;  Jaewoo song  ;  Kyung-A Lee 
Citation
 Annals of Laboratory Medicine, Vol.32(1) : 95-98, 2012 
Journal Title
 Annals of Laboratory Medicine 
ISSN
 2234-3806 
Issue Date
2012
Abstract
The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations.
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DOI
10.3343/alm.2012.32.1.95
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김수정(Kim, Sue Jeong)
김유리(Kim, Yu Ri) ORCID logo https://orcid.org/0000-0001-5505-0142
김주원(Kim, Ju Won)
박서진(Park, Seo Jin)
석윤미(Seok, Yoon Mi)
송재우(Song, Jae Woo) ORCID logo https://orcid.org/0000-0002-1877-5731
이경아(Lee, Kyung A) ORCID logo https://orcid.org/0000-0001-5320-6705
최종락(Choi, Jong Rak) ORCID logo https://orcid.org/0000-0002-0608-2989
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89511
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