Cited 14 times in
CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김유리 | - |
dc.contributor.author | 김주원 | - |
dc.contributor.author | 박서진 | - |
dc.contributor.author | 석윤미 | - |
dc.contributor.author | 송재우 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2014-12-19T16:25:50Z | - |
dc.date.available | 2014-12-19T16:25:50Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89511 | - |
dc.description.abstract | The coexistence of CCND1/IGH and MYC rearrangements in mantle cell lymphoma (MCL) is a rare finding associated with a very poor prognosis. In this study, a patient with blastoid variant (MCL) is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient only survived for 1 month following diagnosis. Conventional cytogenetic study, FISH, and multicolor FISH (mFISH) demonstrated the involvement of the BCL1/CCND1 locus in a complex translocation, t(3;11)(q25;p15)t(11;14)(q13;q32). In addition, subclonal abnormalities in the 8q24 region, manifested as a t(8;14)(q24;q32)/MYC rearrangement, were identified. To the best of our knowledge, this is the first MCL case in Korea bearing these complex genomic aberrations. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | ANNALS OF LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Bone Marrow/immunology | - |
dc.subject.MESH | Bone Marrow/metabolism | - |
dc.subject.MESH | CD5 Antigens/metabolism* | - |
dc.subject.MESH | Chromosomes, Human, Pair 11 | - |
dc.subject.MESH | Chromosomes, Human, Pair 14 | - |
dc.subject.MESH | Chromosomes, Human, Pair 3 | - |
dc.subject.MESH | Gene Rearrangement | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/diagnosis* | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/genetics | - |
dc.subject.MESH | Lymphoma, Mantle-Cell/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oncogene Proteins, Fusion/genetics* | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics* | - |
dc.subject.MESH | Translocation, Genetic | - |
dc.title | CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yoonmi Seok | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.contributor.googleauthor | Seo-Jin Park | - |
dc.contributor.googleauthor | Sue Jung Kim | - |
dc.contributor.googleauthor | Jaewoo song | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.identifier.doi | 10.3343/alm.2012.32.1.95 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00634 | - |
dc.contributor.localId | A00943 | - |
dc.contributor.localId | A01494 | - |
dc.contributor.localId | A01927 | - |
dc.contributor.localId | A02054 | - |
dc.contributor.localId | A02647 | - |
dc.contributor.localId | A04182 | - |
dc.contributor.localId | A00779 | - |
dc.relation.journalcode | J00164 | - |
dc.identifier.eissn | 2234-3814 | - |
dc.identifier.pmid | 22259787 | - |
dc.subject.keyword | CCND1 | - |
dc.subject.keyword | MYC | - |
dc.subject.keyword | Mantle cell lymphoma | - |
dc.contributor.alternativeName | Kim, Sue Jeong | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.alternativeName | Kim, Ju Won | - |
dc.contributor.alternativeName | Park, Seo Jin | - |
dc.contributor.alternativeName | Seok, Yoon Mi | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kim, Sue Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Ju Won | - |
dc.contributor.affiliatedAuthor | Park, Seo Jin | - |
dc.contributor.affiliatedAuthor | Seok, Yoon Mi | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kim, Yu Ri | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 98 | - |
dc.identifier.bibliographicCitation | ANNALS OF LABORATORY MEDICINE, Vol.32(1) : 95-98, 2012 | - |
dc.identifier.rimsid | 31815 | - |
dc.type.rims | ART | - |
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