Cited 0 times in
Minocycline controls clinical outcomes and inflammatory cytokines in moderate and severe meibomian gland dysfunction.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김응권 | - |
dc.contributor.author | 김태임 | - |
dc.contributor.author | 민경 | - |
dc.date.accessioned | 2014-12-19T16:23:21Z | - |
dc.date.available | 2014-12-19T16:23:21Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89433 | - |
dc.description.abstract | PURPOSE: To assess clinical outcomes and tear cytokine levels in patients with moderate and severe meibomian gland dysfunction (MGD) after treatment with oral minocycline and artificial tears versus artificial tears only. DESIGN: Prospective, randomized clinical trial. METHODS: Sixty eyes of 60 patients with stage 3 or 4 meibomian gland dysfunction were enrolled. We evaluated the tear film break-up time, Schirmer test results, corneal and conjunctival fluorescein staining results, biomicroscopic examination results of lid margins and meibomian glands, and tear cytokine levels before and after 1 month and 2 months of oral minocycline and artificial tears (group 1) or artificial tears only (group 2). Tear samples were collected and analyzed using a BD Cytometric Bead Array (BD Bioscience, San Jose, California, USA) for detection of interleukin (IL)-1β, IL-6, IL-7, IL-8, IL-12p70, IL-17α, interferon-γ, tumor necrosis factor-α, and monocyte chemotactic protein-1. The Wilcoxon signed-rank test, Mann-Whitney U test, generalized linear model, and linear mixed model were performed. RESULTS: Patients in group 1 showed statistically significant improvement in all clinical signs and symptoms after 1 month and 2 months of treatment. Patients of group 1 showed more significant improvement compared with those in group 2. Patients in group 1 also showed statistically significant reductions in IL-6, IL-1β, IL-17α, tumor necrosis factor-α, and IL-12p70 after 2 months of treatment. CONCLUSIONS: Oral minocycline can provide clinical benefits in treating moderate and severe meibomian gland dysfunction by reducing inflammatory cytokine levels. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Administration, Oral | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Bacterial Agents/administration & dosage | - |
dc.subject.MESH | Anti-Bacterial Agents/therapeutic use* | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Eye Proteins/metabolism* | - |
dc.subject.MESH | Eyelid Diseases/drug therapy* | - |
dc.subject.MESH | Eyelid Diseases/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Fluorophotometry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Luminescent Measurements | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Meibomian Glands/drug effects* | - |
dc.subject.MESH | Meibomian Glands/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Minocycline/administration & dosage | - |
dc.subject.MESH | Minocycline/therapeutic use* | - |
dc.subject.MESH | Ophthalmic Solutions/administration & dosage | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Tears/metabolism* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Minocycline controls clinical outcomes and inflammatory cytokines in moderate and severe meibomian gland dysfunction. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hun Lee | - |
dc.contributor.googleauthor | Kyung Min | - |
dc.contributor.googleauthor | Eung Kweon Kim | - |
dc.contributor.googleauthor | Tae-Im Kim | - |
dc.identifier.doi | 22967863 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00831 | - |
dc.contributor.localId | A01080 | - |
dc.contributor.localId | A01399 | - |
dc.relation.journalcode | J00097 | - |
dc.identifier.eissn | 1879-1891 | - |
dc.identifier.pmid | 22967863 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0002939412004400 | - |
dc.subject.keyword | Administration, Oral | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Anti-Bacterial Agents/administration & dosage | - |
dc.subject.keyword | Anti-Bacterial Agents/therapeutic use* | - |
dc.subject.keyword | Cytokines/metabolism* | - |
dc.subject.keyword | Eye Proteins/metabolism* | - |
dc.subject.keyword | Eyelid Diseases/drug therapy* | - |
dc.subject.keyword | Eyelid Diseases/metabolism | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Flow Cytometry | - |
dc.subject.keyword | Fluorophotometry | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Luminescent Measurements | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Meibomian Glands/drug effects* | - |
dc.subject.keyword | Meibomian Glands/metabolism | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Minocycline/administration & dosage | - |
dc.subject.keyword | Minocycline/therapeutic use* | - |
dc.subject.keyword | Ophthalmic Solutions/administration & dosage | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Tears/metabolism* | - |
dc.subject.keyword | Treatment Outcome | - |
dc.contributor.alternativeName | Kim, Eung Kweon | - |
dc.contributor.alternativeName | Kim, Tae Im | - |
dc.contributor.alternativeName | Min, Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Eung Kweon | - |
dc.contributor.affiliatedAuthor | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | Min, Kyung | - |
dc.citation.volume | 154 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 949 | - |
dc.citation.endPage | 957 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.154(6) : 949-957, 2012 | - |
dc.identifier.rimsid | 31763 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.