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ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT).

Authors
 Jung-Sun Kim  ;  Byeong-Kuk Kim  ;  Ik-Kyung Jang  ;  Dong-Ho Shin  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Myeong-Ki Hong  ;  Yun-Kyeong Cho  ;  Chang-Wook Nam  ;  Seung-Ho Hur  ;  Jin-Ho Choi  ;  Young Bin Song  ;  Joo Yong Hahn  ;  Seung Hyuk Choi  ;  Hyeon Cheol Gwon  ;  Yangsoo Jang 
Citation
 AMERICAN HEART JOURNAL, Vol.163(4) : 601-607, 2012 
Journal Title
 AMERICAN HEART JOURNAL 
ISSN
 0002-8703 
Issue Date
2012
MeSH
Adult ; Aged ; Coronary Angiography ; Drug-Eluting Stents* ; Everolimus ; Female ; Humans ; Image Processing, Computer-Assisted ; Immunosuppressive Agents/administration & dosage* ; Male ; Middle Aged ; Prospective Studies ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives* ; Tomography, Optical Coherence*
Keywords
Adult ; Aged ; Coronary Angiography ; Drug-Eluting Stents* ; Everolimus ; Female ; Humans ; Image Processing, Computer-Assisted ; Immunosuppressive Agents/administration & dosage* ; Male ; Middle Aged ; Prospective Studies ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives* ; Tomography, Optical Coherence*
Abstract
BACKGROUND: Data on strut surface coverage of second-generation drug-eluting stents (DES) are limited. We investigated stent strut coverage of resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) at 9 months after implantation using optical coherence tomography (OCT). METHODS: ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT) is a prospective, randomized, multicenter trial comparing ZES-R to EES using OCT at 9 months after stent implantation. The primary end point was the rate of stent strut coverage at 9 months. RESULTS: A total of 51 patients were randomized to receive either ZES-R (ZES-R group) or EES (EES group), and 47 stents (24 ZES-R and 23 EES) in 44 of 51 patients were evaluated by OCT both immediately after stent implantation and at 9 months. The neointimal thickness was not significantly different between the 2 groups at 9 months (ZES-R vs EES: 139 ± 58 vs 124 ± 42 μm, P = .31). The mean percentages of uncovered stent struts were 3.3% for ZES-R versus 3.4% for EES at 9 months (P = .51). The proportions of malapposed struts immediately after stent implantation (P = .89) and at 9-month follow-up (P = .34) were 0.8% and 0.7% for ZES-R versus 1.0% and 0.1% for EES, respectively. Thrombi were documented in 1 stent (1 [4.2%] in ZES-R vs 0 [0%] in EES). CONCLUSION: According to the sequential OCT evaluation, ZES-R and EES showed comparable neointimal thickness and the rate of uncovered stent strut at 9 months after stent implantation.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002870311007769
DOI
22520526
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89406
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