Short communication: factors influencing time to CD4(+) T cell counts >200 cells/mm(3) in HIV-infected individuals with CD4(+) T cell <50 cells/mm(3) at the time of starting combination antiretroviral therapy

Nam Su Ku; Young Goo Song; Sang Hoon Han; Sun Bean Kim; Hye-won Kim; Su Jin Jeong; Chang Oh Kim; June Myung Kim; Jun Yong Choi

doi:22632127

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Short communication: factors influencing time to CD4(+) T cell counts >200 cells/mm(3) in HIV-infected individuals with CD4(+) T cell <50 cells/mm(3) at the time of starting combination antiretroviral therapy

Authors: Nam Su Ku ; Young Goo Song ; Sang Hoon Han ; Sun Bean Kim ; Hye-won Kim ; Su Jin Jeong ; Chang Oh Kim ; June Myung Kim ; Jun Yong Choi

Citation: AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol.28(12) : 1594-1597, 2012

Journal Title: AIDS RESEARCH AND HUMAN RETROVIRUSES

ISSN: 0889-2229

Issue Date: 2012

MeSH: Adult ; Aged ; Anti-Retroviral Agents/administration & dosage* ; Antiretroviral Therapy, Highly Active* ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology* ; Case-Control Studies ; Female ; HIV Infections/drug therapy* ; HIV Infections/immunology* ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome

Keywords: Adult ; Aged ; Anti-Retroviral Agents/administration & dosage* ; Antiretroviral Therapy, Highly Active* ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology* ; Case-Control Studies ; Female ; HIV Infections/drug therapy* ; HIV Infections/immunology* ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome

Abstract: We evaluated factors influencing time to CD4(+) T cell counts >200 cells/mm(3) in HIV-infected individuals with CD4(+) T cell <50 cells/mm(3) starting combination antiretroviral therapy (cART). We included a total of 29 patients on successful cART for more than 1 year. In a logistic regression model, higher pre-cART CD4(+) T cell counts were significantly associated with shorter time to CD4(+) T cell counts >200cells/mm(3) in HIV-infected individuals with baseline CD4(+) T cell <50 cells/mm(3). In survival analysis, patients having higher pre-cART CD4(+) T cell counts, especially 40-49 cells/mm(3), were at significantly higher risk of achieving CD4(+) T cell counts >200 cells/mm(3).