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Initially non-diagnostic ultrasound-guided fine needle aspiration cytology of thyroid nodules: value and management.

DC FieldValueLanguage
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author김정아-
dc.contributor.author손은주-
dc.contributor.author유영훈-
dc.contributor.author육지현-
dc.contributor.author정진-
dc.date.accessioned2014-12-19T16:21:45Z-
dc.date.available2014-12-19T16:21:45Z-
dc.date.issued2012-
dc.identifier.issn0284-1851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89384-
dc.description.abstractBACKGROUND: Ultrasound (US)-guided fine needle aspiration cytology (FNAC) is an accurate, reliable, and simple method to identify a thyroid nodule as benign or malignant. However, non-diagnostic cytology results for thyroid nodules are a major limitation of US-guided FNAC. PURPOSE: To investigate the incidence of thyroid cancer among cases with non-diagnostic results on FNAC and to provide suggestions for the management of thyroid nodules that are initially non-diagnostic by FNAC according to ultrasonographic findings. MATERIAL AND METHODS: From July 2006 to December 2009, 10,317 thyroid nodules in 6684 consecutive patients underwent US-guided FNAC at our institute. Among these, 871 thyroid nodules (8.4%) were diagnosed as non-diagnostic on initial cytologic evaluation and 196 underwent a second or third FNAC. Twenty-seven thyroid nodules (18.9%) underwent surgery, while 116 thyroid nodules were cytologically confirmed as benign with no remarkable change on follow-up US were included. We retrospectively reviewed the US findings for a total of 143 thyroid nodules (123 benign nodules and 20 malignant nodules). The US features that we compared included composition, echogenicity, margin, calcifications, shape, and underlying echogenicity. RESULTS: In total, thyroid cancer was diagnosed in 20 nodules (14.0%). The size of the nodule was significantly associated with malignancy (P < 0.05). Most of the sonographically probable benign nodules were found to be benign (97.6%). Suspicious nodules on US were thyroid cancer in 43.2% of cases. Marked hypoechogenicity, microlobulated or irregular margin, microcalcifications, and taller-than-wide shape were significant US findings that correlated with malignancy (P < 0.05). The diagnostic performance of ultrasound for initially non-diagnostic thyroid nodules was as follows: sensitivity of 90.0%, specificity of 65.0%, positive predictive value of 29.5%, and negative predictive value of 97.6%. CONCLUSION: In terms of management of thyroid nodules with non-diagnostic FNAC cytology, US evaluation is a feasible and useful method for predicting malignancy.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfACTA RADIOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHCytodiagnosis/methods*-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHDisease Management-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHThyroid Gland/pathology-
dc.subject.MESHThyroid Nodule/diagnostic imaging*-
dc.subject.MESHThyroid Nodule/epidemiology-
dc.subject.MESHThyroid Nodule/pathology*-
dc.subject.MESHUltrasonography, Interventional/methods*-
dc.titleInitially non-diagnostic ultrasound-guided fine needle aspiration cytology of thyroid nodules: value and management.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJin Chung-
dc.contributor.googleauthorJi Hyun Youk-
dc.contributor.googleauthorJeong-Ah Kim-
dc.contributor.googleauthorJin Young Kwak-
dc.contributor.googleauthorEun-kyung Kim-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorEun Ju Son-
dc.identifier.doi21969700-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA00888-
dc.contributor.localIdA01988-
dc.contributor.localIdA02485-
dc.contributor.localIdA02537-
dc.contributor.localIdA03740-
dc.relation.journalcodeJ00033-
dc.identifier.eissn1600-0455-
dc.identifier.pmid21969700-
dc.subject.keywordThyroid-
dc.subject.keywordfine needle aspiration cytology-
dc.subject.keywordsonography-
dc.subject.keywordthyroid cancer-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameKim, Jeong Ah-
dc.contributor.alternativeNameSon, Eun Ju-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameYouk, Ji Hyun-
dc.contributor.alternativeNameChung, Jin-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorKim, Jeong Ah-
dc.contributor.affiliatedAuthorSon, Eun Ju-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorYouk, Ji Hyun-
dc.contributor.affiliatedAuthorChung, Jin-
dc.citation.volume53-
dc.citation.number2-
dc.citation.startPage168-
dc.citation.endPage173-
dc.identifier.bibliographicCitationACTA RADIOLOGICA, Vol.53(2) : 168-173, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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