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Initially non-diagnostic ultrasound-guided fine needle aspiration cytology of thyroid nodules: value and management.
DC Field | Value | Language |
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dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 김정아 | - |
dc.contributor.author | 손은주 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 육지현 | - |
dc.contributor.author | 정진 | - |
dc.date.accessioned | 2014-12-19T16:21:45Z | - |
dc.date.available | 2014-12-19T16:21:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89384 | - |
dc.description.abstract | BACKGROUND: Ultrasound (US)-guided fine needle aspiration cytology (FNAC) is an accurate, reliable, and simple method to identify a thyroid nodule as benign or malignant. However, non-diagnostic cytology results for thyroid nodules are a major limitation of US-guided FNAC. PURPOSE: To investigate the incidence of thyroid cancer among cases with non-diagnostic results on FNAC and to provide suggestions for the management of thyroid nodules that are initially non-diagnostic by FNAC according to ultrasonographic findings. MATERIAL AND METHODS: From July 2006 to December 2009, 10,317 thyroid nodules in 6684 consecutive patients underwent US-guided FNAC at our institute. Among these, 871 thyroid nodules (8.4%) were diagnosed as non-diagnostic on initial cytologic evaluation and 196 underwent a second or third FNAC. Twenty-seven thyroid nodules (18.9%) underwent surgery, while 116 thyroid nodules were cytologically confirmed as benign with no remarkable change on follow-up US were included. We retrospectively reviewed the US findings for a total of 143 thyroid nodules (123 benign nodules and 20 malignant nodules). The US features that we compared included composition, echogenicity, margin, calcifications, shape, and underlying echogenicity. RESULTS: In total, thyroid cancer was diagnosed in 20 nodules (14.0%). The size of the nodule was significantly associated with malignancy (P < 0.05). Most of the sonographically probable benign nodules were found to be benign (97.6%). Suspicious nodules on US were thyroid cancer in 43.2% of cases. Marked hypoechogenicity, microlobulated or irregular margin, microcalcifications, and taller-than-wide shape were significant US findings that correlated with malignancy (P < 0.05). The diagnostic performance of ultrasound for initially non-diagnostic thyroid nodules was as follows: sensitivity of 90.0%, specificity of 65.0%, positive predictive value of 29.5%, and negative predictive value of 97.6%. CONCLUSION: In terms of management of thyroid nodules with non-diagnostic FNAC cytology, US evaluation is a feasible and useful method for predicting malignancy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA RADIOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Cytodiagnosis/methods* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Disease Management | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Thyroid Gland/pathology | - |
dc.subject.MESH | Thyroid Nodule/diagnostic imaging* | - |
dc.subject.MESH | Thyroid Nodule/epidemiology | - |
dc.subject.MESH | Thyroid Nodule/pathology* | - |
dc.subject.MESH | Ultrasonography, Interventional/methods* | - |
dc.title | Initially non-diagnostic ultrasound-guided fine needle aspiration cytology of thyroid nodules: value and management. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jin Chung | - |
dc.contributor.googleauthor | Ji Hyun Youk | - |
dc.contributor.googleauthor | Jeong-Ah Kim | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.contributor.googleauthor | Eun-kyung Kim | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Eun Ju Son | - |
dc.identifier.doi | 21969700 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A00888 | - |
dc.contributor.localId | A01988 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02537 | - |
dc.contributor.localId | A03740 | - |
dc.relation.journalcode | J00033 | - |
dc.identifier.eissn | 1600-0455 | - |
dc.identifier.pmid | 21969700 | - |
dc.subject.keyword | Thyroid | - |
dc.subject.keyword | fine needle aspiration cytology | - |
dc.subject.keyword | sonography | - |
dc.subject.keyword | thyroid cancer | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Kim, Jeong Ah | - |
dc.contributor.alternativeName | Son, Eun Ju | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Youk, Ji Hyun | - |
dc.contributor.alternativeName | Chung, Jin | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ah | - |
dc.contributor.affiliatedAuthor | Son, Eun Ju | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Youk, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Jin | - |
dc.citation.volume | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 168 | - |
dc.citation.endPage | 173 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, Vol.53(2) : 168-173, 2012 | - |
dc.identifier.rimsid | 34603 | - |
dc.type.rims | ART | - |
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