170 303

Cited 0 times in

Expression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy

DC FieldValueLanguage
dc.contributor.author변석호-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author전익현-
dc.contributor.author고형준-
dc.contributor.author김태임-
dc.date.accessioned2014-12-19T16:21:34Z-
dc.date.available2014-12-19T16:21:34Z-
dc.date.issued2012-
dc.identifier.issn1755-375X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89378-
dc.description.abstractPURPOSE: To determine the aqueous humour levels of 12 cytokines in eyes with uveal melanoma and whether their expression changes after combined Ru-106 brachytherapy and transpupillary thermotherapy (TTT). METHODS: Aqueous humour samples were collected from 20 patients with previously untreated uveal melanoma undergoing combined Ru-106 brachytherapy and TTT, both at the time of plaque placement and removal. Using multiplex biochip array technology, 12 different cytokines were measured, including interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), tumour necrosis factor (TNF)-α, interferon (IFN)-γ, epidermal growth factor (EGF) and monocyte chemoattractant protein (MCP)-1. Aqueous humour from 20 patients undergoing cataract surgery was used as control. RESULTS: IL-6, IL-8, IFN-γ and MCP-1 were highly expressed in uveal melanoma, whereas IL-2, IL-10 and TNF- α were low in expression. There was a positive correlation between tumour height and IL-8 level (p = 0.020). Vascular endothelial growth factor tends to be highly expressed in melanoma-containing eyes (p = 0.056). Levels of IL-6, IL-8 and IL-1β increased after the mean 117 ± 38 hrs of brachytherapy and adjunctive TTT with a tumour apex dose of 61 ± 28 Gy and a scleral contact dose of 786 ± 226 Gy. Increase in levels of IL-6 (p = 0.003) and IL-8 (p = 0.046) positively correlated with scleral contact dose. CONCLUSIONS: Cytokines such as IL-6, IL-8, IFN-γ and MCP-1 may be implicated in the progression of uveal melanoma. Ocular irradiation from a Ru-106 plaque promoted an increase in the levels of IL-6, IL-8 and IL-1β, modulation of which could be useful in managing radiation-related side effects.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfACTA OPHTHALMOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAqueous Humor/metabolism*-
dc.subject.MESHBrachytherapy*-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHCytokines/metabolism*-
dc.subject.MESHEye Proteins/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperthermia, Induced*-
dc.subject.MESHMale-
dc.subject.MESHMelanoma/metabolism*-
dc.subject.MESHMelanoma/radiotherapy-
dc.subject.MESHMelanoma/therapy-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProtein Array Analysis-
dc.subject.MESHRuthenium Radioisotopes/therapeutic use-
dc.subject.MESHUveal Neoplasms/metabolism*-
dc.subject.MESHUveal Neoplasms/radiotherapy-
dc.subject.MESHUveal Neoplasms/therapy-
dc.titleExpression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.contributor.googleauthorIk Hyun Jun-
dc.contributor.googleauthorTae-im Kim-
dc.contributor.googleauthorSuk Ho Byeon-
dc.contributor.googleauthorHyoung Jun Koh-
dc.contributor.googleauthorSung Chul Lee-
dc.identifier.doi22429778-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01849-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA00152-
dc.contributor.localIdA01080-
dc.contributor.localIdA03541-
dc.relation.journalcodeJ00025-
dc.identifier.eissn1755-3768-
dc.identifier.pmid22429778-
dc.subject.keywordangiogenesis-
dc.subject.keywordbrachytherapy-
dc.subject.keywordcytokine-
dc.subject.keywordinflammation-
dc.subject.keyworduveal melanoma-
dc.contributor.alternativeNameByeon, Suk Ho-
dc.contributor.alternativeNameLee, Sung Chul-
dc.contributor.alternativeNameLee, Seung Kyu-
dc.contributor.alternativeNameJun, Ik Hyun-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.alternativeNameKim, Tae Im-
dc.contributor.affiliatedAuthorByeon, Suk Ho-
dc.contributor.affiliatedAuthorLee, Sung Chul-
dc.contributor.affiliatedAuthorLee, Seung Kyu-
dc.contributor.affiliatedAuthorKoh, Hyoung Jun-
dc.contributor.affiliatedAuthorKim, Tae Im-
dc.contributor.affiliatedAuthorJun, Ik Hyun-
dc.citation.volume90-
dc.citation.number4-
dc.citation.startPage314-
dc.citation.endPage320-
dc.identifier.bibliographicCitationACTA OPHTHALMOLOGICA, Vol.90(4) : 314-320, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.