Cited 27 times in
Expression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 변석호 | - |
dc.contributor.author | 이성철 | - |
dc.contributor.author | 이승규 | - |
dc.contributor.author | 전익현 | - |
dc.contributor.author | 고형준 | - |
dc.contributor.author | 김태임 | - |
dc.date.accessioned | 2014-12-19T16:21:34Z | - |
dc.date.available | 2014-12-19T16:21:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1755-375X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89378 | - |
dc.description.abstract | PURPOSE: To determine the aqueous humour levels of 12 cytokines in eyes with uveal melanoma and whether their expression changes after combined Ru-106 brachytherapy and transpupillary thermotherapy (TTT). METHODS: Aqueous humour samples were collected from 20 patients with previously untreated uveal melanoma undergoing combined Ru-106 brachytherapy and TTT, both at the time of plaque placement and removal. Using multiplex biochip array technology, 12 different cytokines were measured, including interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), tumour necrosis factor (TNF)-α, interferon (IFN)-γ, epidermal growth factor (EGF) and monocyte chemoattractant protein (MCP)-1. Aqueous humour from 20 patients undergoing cataract surgery was used as control. RESULTS: IL-6, IL-8, IFN-γ and MCP-1 were highly expressed in uveal melanoma, whereas IL-2, IL-10 and TNF- α were low in expression. There was a positive correlation between tumour height and IL-8 level (p = 0.020). Vascular endothelial growth factor tends to be highly expressed in melanoma-containing eyes (p = 0.056). Levels of IL-6, IL-8 and IL-1β increased after the mean 117 ± 38 hrs of brachytherapy and adjunctive TTT with a tumour apex dose of 61 ± 28 Gy and a scleral contact dose of 786 ± 226 Gy. Increase in levels of IL-6 (p = 0.003) and IL-8 (p = 0.046) positively correlated with scleral contact dose. CONCLUSIONS: Cytokines such as IL-6, IL-8, IFN-γ and MCP-1 may be implicated in the progression of uveal melanoma. Ocular irradiation from a Ru-106 plaque promoted an increase in the levels of IL-6, IL-8 and IL-1β, modulation of which could be useful in managing radiation-related side effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | ACTA OPHTHALMOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aqueous Humor/metabolism* | - |
dc.subject.MESH | Brachytherapy* | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Eye Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperthermia, Induced* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melanoma/metabolism* | - |
dc.subject.MESH | Melanoma/radiotherapy | - |
dc.subject.MESH | Melanoma/therapy | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Protein Array Analysis | - |
dc.subject.MESH | Ruthenium Radioisotopes/therapeutic use | - |
dc.subject.MESH | Uveal Neoplasms/metabolism* | - |
dc.subject.MESH | Uveal Neoplasms/radiotherapy | - |
dc.subject.MESH | Uveal Neoplasms/therapy | - |
dc.title | Expression of 12 cytokines in aqueous humour of uveal melanoma before and after combined Ruthenium-106 brachytherapy and transpupillary thermotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Christopher Seungkyu Lee | - |
dc.contributor.googleauthor | Ik Hyun Jun | - |
dc.contributor.googleauthor | Tae-im Kim | - |
dc.contributor.googleauthor | Suk Ho Byeon | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.contributor.googleauthor | Sung Chul Lee | - |
dc.identifier.doi | 10.1111/j.1755-3768.2012.02392.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01849 | - |
dc.contributor.localId | A02873 | - |
dc.contributor.localId | A02913 | - |
dc.contributor.localId | A00152 | - |
dc.contributor.localId | A01080 | - |
dc.contributor.localId | A03541 | - |
dc.relation.journalcode | J00025 | - |
dc.identifier.eissn | 1755-3768 | - |
dc.identifier.pmid | 22429778 | - |
dc.subject.keyword | angiogenesis | - |
dc.subject.keyword | brachytherapy | - |
dc.subject.keyword | cytokine | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | uveal melanoma | - |
dc.contributor.alternativeName | Byeon, Suk Ho | - |
dc.contributor.alternativeName | Lee, Sung Chul | - |
dc.contributor.alternativeName | Lee, Seung Kyu | - |
dc.contributor.alternativeName | Jun, Ik Hyun | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.alternativeName | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | Byeon, Suk Ho | - |
dc.contributor.affiliatedAuthor | Lee, Sung Chul | - |
dc.contributor.affiliatedAuthor | Lee, Seung Kyu | - |
dc.contributor.affiliatedAuthor | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | Kim, Tae Im | - |
dc.contributor.affiliatedAuthor | Jun, Ik Hyun | - |
dc.citation.volume | 90 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 314 | - |
dc.citation.endPage | 320 | - |
dc.identifier.bibliographicCitation | ACTA OPHTHALMOLOGICA, Vol.90(4) : 314-320, 2012 | - |
dc.identifier.rimsid | 34599 | - |
dc.type.rims | ART | - |
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