11 239

Cited 0 times in

Striatal dopamine loss and discriminative sensory dysfunction in Parkinson's disease

 C. H. Lyoo  ;  Y. H. Ryu  ;  M. J. Lee  ;  M. S. Lee 
 ACTA NEUROLOGICA SCANDINAVICA, Vol.126(5) : 344-349, 2012 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Corpus Striatum/chemistry ; Corpus Striatum/diagnostic imaging* ; Corpus Striatum/metabolism ; Dopamine/metabolism* ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Female ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged ; Parkinson Disease/complications* ; Parkinson Disease/metabolism* ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/therapeutic use ; Sensation Disorders/etiology* ; Sensation Disorders/metabolism ; Touch Perception/physiology ; Tropanes
Parkinsons disease ; temporaldiscrimination threshold ; dopamine transporterimaging
OBJECTIVES: Patients with Parkinson's disease (PD) have higher-order discriminative sensory dysfunction including prolonged somesthetic temporal discrimination threshold (sTDT). We studied the effect of striatal dopamine loss on the prolongation of sTDT and also studied the impact of prolonged sTDT values on the various parkinsonian motor deficits. MATERIALS AND METHODS: In 30 patients with PD, the severity of parkinsonian motor deficits was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores during levodopa off and on periods. The UPDRS motor subscores were calculated, representing bradykinesia, rigidity, tremor, and axial motor deficits. During levodopa off and on periods, the sTDT value of each index finger was studied. Using [(18) F]-N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane (FPCIT) positron emission tomography studies, caudate and putaminal dopamine transporter uptake levels were measured. Multiple regression analysis covariated with age was used for statistical analysis. RESULTS: During the off period, the striatal FPCIT uptake levels had an impact on the sTDT values (P < 0.01). The sTDT values had an impact on the UPDRS subscores for axial motor deficits (P < 0.05), but had no impact on those for bradykinesia, rigidity, and tremor. The sTDT values as well as UPDRS total motor scores and all UPDRS subscores were improved by a single oral levodopa treatment. CONCLUSIONS: Striatal dopamine deficiency and consequent basal ganglia dysfunction may prolong sTDT, and higher-order discriminative sensory dysfunction seems to contribute in part to the development of axial motor deficits in patients with PD.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Myung Jun(이명준)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.