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Consecutive targetable smart nanoprobe for molecular recognition of cytoplasmic microRNA in metastatic breast cancer

DC Field Value Language
dc.contributor.author김남희-
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author육종인-
dc.contributor.author허용민-
dc.date.accessioned2014-12-19T16:20:21Z-
dc.date.available2014-12-19T16:20:21Z-
dc.date.issued2012-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89342-
dc.description.abstractWe report smart nanoprobe, hyaluronic acid (HA)-based nanocontainers containing miR-34a beacons (bHNCs), for the intracellular recognition of miR-34a levels in metastatic breast cancer cells, which is distinct from the imaging of biomarkers such of cell membrane receptors such as HER2. In this study, we demonstrate that a nanoscale vesicle that couples a targeting endocytic route, CD44, and a molecular imaging probe enables the efficient detection of specific miRNAs. Furthermore, bHNCs showed no cytotoxicity and high stability due to the anchored HA molecules on the surface of nanocontainers, and enables the targeted delivery of beacons via CD44 receptor-mediated endocytosis. In vitro and in vivo optical imaging using bHNCs also allow the measurement of miR-34a expression levels due to the selective recognition of the beacons released from the internalized bHNCs. We believe that the technique described herein can be further developed as a cancer diagnostic as well as a miRNA-based therapy of metastatic cancer.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfACS NANO-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBreast Neoplasms/diagnosis*-
dc.subject.MESHBreast Neoplasms/genetics-
dc.subject.MESHBreast Neoplasms/secondary*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMicroRNAs/analysis*-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHMicroscopy, Fluorescence/methods*-
dc.subject.MESHMolecular Imaging/methods*-
dc.subject.MESHNanocapsules*/chemistry-
dc.titleConsecutive targetable smart nanoprobe for molecular recognition of cytoplasmic microRNA in metastatic breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEunjung Kim-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorJoseph Park-
dc.contributor.googleauthorSoonhag Kim-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorSeungjoo Haam-
dc.contributor.googleauthorYong-Min Huh-
dc.identifier.doi22947044-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00360-
dc.contributor.localIdA01916-
dc.contributor.localIdA02536-
dc.contributor.localIdA04359-
dc.contributor.localIdA02315-
dc.relation.journalcodeJ00005-
dc.identifier.eissn1936-086X-
dc.identifier.pmid22947044-
dc.identifier.urlhttp://pubs.acs.org/doi/abs/10.1021/nn300289u-
dc.subject.keywordhyaluronic acid-
dc.subject.keywordintracellular imaging-
dc.subject.keywordmiR-34a-
dc.subject.keywordmolecular beacon-
dc.subject.keywordnanocontainer-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorKim, Nam Hee-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.citation.volume6-
dc.citation.number10-
dc.citation.startPage8525-
dc.citation.endPage8535-
dc.identifier.bibliographicCitationACS NANO, Vol.6(10) : 8525-8535, 2012-
dc.identifier.rimsid34546-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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