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Muscle strength and quality are associated with severity of menopausal symptoms in peri- and post-menopausal women

Authors
 Jee-Yon Lee  ;  Duk-Chul Lee 
Citation
 MATURITAS, Vol.76(1) : 88-94, 2013 
Journal Title
 MATURITAS 
ISSN
 0378-5122 
Issue Date
2013
MeSH
Cross-Sectional Studies ; Depression ; Female ; Hand Strength* ; Hot Flashes ; Humans ; Logistic Models ; Menopause ; Middle Aged ; Muscle, Skeletal/physiology* ; Odds Ratio ; Postmenopause/physiology* ; Postmenopause/psychology ; Sarcopenia/physiopathology* ; Severity of Illness Index*
Keywords
Kupperman index scores ; Menopausal symptom ; Muscle quality ; Muscle strength ; Sarcopenia
Abstract
OBJECTIVES: Menopausal symptoms are common and affect the quality of life of menopausal women. Menopausal symptoms are associated with age-related conditions. Sarcopenia, loss of muscle mass and/or function, is also associated with several age-related conditions, suggesting that the severity of menopausal symptoms may be associated with sarcopenia. Therefore, we investigated the relationship between Kupperman index scores, a measure of menopausal symptom severity, and muscle strength and quality in peri- and post-menopausal women. STUDY DESIGN: Cross-sectional study. MAIN OUTCOME MEASURES: A total of 148 women participated. Biomarkers of metabolic risk factors were assessed along with muscle mass as measured with Dual-energy X-ray Absorptiometry. Handgrip strength was measured with isometric dynamometry. Muscle quality was calculated as the ratio of strength to muscle mass in upper extremities. RESULTS: Kupperman index scores correlated with the depression scale, handgrip strength, and specific force after adjusting for age and body mass index. Mean handgrip strength and specific force decreased gradually according to menopausal symptom severity. Multivariate logistic regression analysis showed that the fourth handgrip strength and specific force quartiles were associated with the prevalence of severe menopausal symptoms with adjusted odds ratios of 0.14 (95% confidence interval 0.03-0.68) and 0.09 (95% confidence interval 0.03-0.47), respectively. CONCLUSIONS: Lower handgrip strength was associated with severe menopausal symptoms. Although we could not determine causality, muscle strength and quality during menopause may be related to the severity of menopausal symptoms. Further interventional and experimental studies are required to understand the clinical and pathophysiological significance of our findings.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378512213001916
DOI
10.1016/j.maturitas.2013.06.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Jee Yon(이지연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89335
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