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Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up

 Jung Woo Han  ;  Hyo Sun Kim  ;  Beom Sik Kim  ;  Seung Yeon Kwon  ;  Yoon Jung Shin  ;  Sun Hee Kim  ;  Jong Hee Ko  ;  Chuhl Joo Lyu 
 Journal of Korean Medical Science, Vol.28(5) : 755-762, 2013 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adolescent ; Age Factors ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Brain Neoplasms/radiotherapy ; Child ; Child, Preschool ; Disease Progression ; Female ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology ; Humans ; Infant ; Infant, Newborn ; Lymphoma/mortality ; Lymphoma/pathology ; Lymphoma/radiotherapy ; Male ; Multivariate Analysis ; Neoplasms/mortality ; Neoplasms/pathology* ; Neoplasms/radiotherapy ; Risk Factors ; Severity of Illness Index ; Survival Rate
Complications ; Health ; Late Effects ; Morbidity ; Neoplasms ; Survivors
Recent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Seung Yeon(권승연)
Kim, Beom Sik(김범식)
Kim, Hyo Sun(김효선)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
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