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Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up

DC FieldValueLanguage
dc.contributor.author권승연-
dc.contributor.author김범식-
dc.contributor.author김효선-
dc.contributor.author유철주-
dc.contributor.author한정우-
dc.date.accessioned2014-12-18T10:02:13Z-
dc.date.available2014-12-18T10:02:13Z-
dc.date.issued2013-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89294-
dc.description.abstractRecent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAge Factors-
dc.subject.MESHBrain Neoplasms/mortality-
dc.subject.MESHBrain Neoplasms/pathology-
dc.subject.MESHBrain Neoplasms/radiotherapy-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHematopoietic Stem Cell Transplantation-
dc.subject.MESHHematopoietic Stem Cells/cytology-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHLymphoma/mortality-
dc.subject.MESHLymphoma/pathology-
dc.subject.MESHLymphoma/radiotherapy-
dc.subject.MESHMale-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasms/mortality-
dc.subject.MESHNeoplasms/pathology*-
dc.subject.MESHNeoplasms/radiotherapy-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSurvival Rate-
dc.titleIncreasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorHyo Sun Kim-
dc.contributor.googleauthorBeom Sik Kim-
dc.contributor.googleauthorSeung Yeon Kwon-
dc.contributor.googleauthorYoon Jung Shin-
dc.contributor.googleauthorSun Hee Kim-
dc.contributor.googleauthorJong Hee Ko-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.identifier.doi10.3346/jkms.2013.28.5.755-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04325-
dc.contributor.localIdA00226-
dc.contributor.localIdA00490-
dc.contributor.localIdA01201-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid23678269-
dc.subject.keywordComplications-
dc.subject.keywordHealth-
dc.subject.keywordLate Effects-
dc.subject.keywordMorbidity-
dc.subject.keywordNeoplasms-
dc.subject.keywordSurvivors-
dc.contributor.alternativeNameKwon, Seung Yeon-
dc.contributor.alternativeNameKim, Beom Sik-
dc.contributor.alternativeNameKim, Hyo Sun-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthorKwon, Seung Yeon-
dc.contributor.affiliatedAuthorKim, Beom Sik-
dc.contributor.affiliatedAuthorKim, Hyo Sun-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.rights.accessRightsfree-
dc.citation.volume28-
dc.citation.number5-
dc.citation.startPage755-
dc.citation.endPage762-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.28(5) : 755-762, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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