Cited 6 times in
Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권승연 | - |
dc.contributor.author | 김범식 | - |
dc.contributor.author | 김효선 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 한정우 | - |
dc.date.accessioned | 2014-12-18T10:02:13Z | - |
dc.date.available | 2014-12-18T10:02:13Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89294 | - |
dc.description.abstract | Recent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Brain Neoplasms/mortality | - |
dc.subject.MESH | Brain Neoplasms/pathology | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation | - |
dc.subject.MESH | Hematopoietic Stem Cells/cytology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Infant, Newborn | - |
dc.subject.MESH | Lymphoma/mortality | - |
dc.subject.MESH | Lymphoma/pathology | - |
dc.subject.MESH | Lymphoma/radiotherapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasms/mortality | - |
dc.subject.MESH | Neoplasms/pathology* | - |
dc.subject.MESH | Neoplasms/radiotherapy | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Beom Sik Kim | - |
dc.contributor.googleauthor | Seung Yeon Kwon | - |
dc.contributor.googleauthor | Yoon Jung Shin | - |
dc.contributor.googleauthor | Sun Hee Kim | - |
dc.contributor.googleauthor | Jong Hee Ko | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.identifier.doi | 10.3346/jkms.2013.28.5.755 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A00226 | - |
dc.contributor.localId | A00490 | - |
dc.contributor.localId | A01201 | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 23678269 | - |
dc.subject.keyword | Complications | - |
dc.subject.keyword | Health | - |
dc.subject.keyword | Late Effects | - |
dc.subject.keyword | Morbidity | - |
dc.subject.keyword | Neoplasms | - |
dc.subject.keyword | Survivors | - |
dc.contributor.alternativeName | Kwon, Seung Yeon | - |
dc.contributor.alternativeName | Kim, Beom Sik | - |
dc.contributor.alternativeName | Kim, Hyo Sun | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kwon, Seung Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Beom Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Sun | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 755 | - |
dc.citation.endPage | 762 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.28(5) : 755-762, 2013 | - |
dc.identifier.rimsid | 34511 | - |
dc.type.rims | ART | - |
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