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Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans

Authors
 Sang-Jin Lee  ;  Jae Young Joung  ;  Hyekyoung Yoon  ;  Jeong Eun Kim  ;  Weon Seo Park  ;  Ho Kyung Seo  ;  Jinsoo Chung  ;  Jung-Ah Hwang  ;  Seung-Hyun Hong  ;  Seungyoon Nam  ;  Sohee Park  ;  Jeongseon Kim  ;  Kang Hyun Lee  ;  Yeon-Su Lee 
Citation
 BIOMED RESEARCH INTERNATIONAL, Vol.2013 : 394285, 2013 
Journal Title
 BIOMED RESEARCH INTERNATIONAL 
ISSN
 2314-6133 
Issue Date
2013
MeSH
Aged ; Alleles ; Asian Continental Ancestry Group/genetics ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies* ; Genetic Predisposition to Disease* ; Genotype ; Haplotypes ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prostatectomy ; Prostatic Neoplasms/genetics* ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Racemases and Epimerases/genetics* ; Risk Factors
Keywords
Aged ; Alleles ; Asian Continental Ancestry Group/genetics ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies* ; Genetic Predisposition to Disease* ; Genotype ; Haplotypes ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prostatectomy ; Prostatic Neoplasms/genetics* ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Racemases and Epimerases/genetics* ; Risk Factors
Abstract
Background. To assess if the variants of (R)-alpha-methyl-CoA racemase (AMACR) gene would be associated with the risk of sporadic prostate cancer in ethnically homogenous Koreans. Materials and Methods. We enrolled 194 patients with prostate cancer and 169 healthy controls. A total of 17 single nucleotide polymorphisms of the AMACR gene were selected. The distribution of each genotype and haplotype was analyzed and their association with the incidence of prostate cancer was evaluated. Further, we detected AMACR expression in tumor with immunohistochemistry and analyzed its association with genotype regarding prostate cancer risk. Results. AG or GG genotype of rs2278008 (E277K) tended to lower prostate cancer risk. The minor G allele was found to be a significant allele that decreased the risk of prostate cancer (adjusted OR, 0.57; 95% CI, 0.35–0.93, value = 0.025). In patients expression AMACR, AG or GG genotype was also significant genotype in terms of prostate cancer risk (adjusted OR, 0.47; 95% CI, 0.26–0.87, value = 0.017). Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer ( value = 0.047). Conclusions. Genetic variations of AMACR are associated with the risk of sporadic prostate cancer that underwent radical prostatectomy in Koreans.
Files in This Item:
T201305669.pdf Download
DOI
10.1155/2013/394285
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Park, So Hee(박소희) ORCID logo https://orcid.org/0000-0001-8513-5163
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89170
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