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Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans

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dc.contributor.author박소희-
dc.date.accessioned2014-12-18T09:58:07Z-
dc.date.available2014-12-18T09:58:07Z-
dc.date.issued2013-
dc.identifier.issn2314-6133-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89170-
dc.description.abstractBackground. To assess if the variants of (R)-alpha-methyl-CoA racemase (AMACR) gene would be associated with the risk of sporadic prostate cancer in ethnically homogenous Koreans. Materials and Methods. We enrolled 194 patients with prostate cancer and 169 healthy controls. A total of 17 single nucleotide polymorphisms of the AMACR gene were selected. The distribution of each genotype and haplotype was analyzed and their association with the incidence of prostate cancer was evaluated. Further, we detected AMACR expression in tumor with immunohistochemistry and analyzed its association with genotype regarding prostate cancer risk. Results. AG or GG genotype of rs2278008 (E277K) tended to lower prostate cancer risk. The minor G allele was found to be a significant allele that decreased the risk of prostate cancer (adjusted OR, 0.57; 95% CI, 0.35–0.93, value = 0.025). In patients expression AMACR, AG or GG genotype was also significant genotype in terms of prostate cancer risk (adjusted OR, 0.47; 95% CI, 0.26–0.87, value = 0.017). Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer ( value = 0.047). Conclusions. Genetic variations of AMACR are associated with the risk of sporadic prostate cancer that underwent radical prostatectomy in Koreans.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfBIOMED RESEARCH INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGenetic Association Studies*-
dc.subject.MESHGenetic Predisposition to Disease*-
dc.subject.MESHGenotype-
dc.subject.MESHHaplotypes-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHProstatectomy-
dc.subject.MESHProstatic Neoplasms/genetics*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHProstatic Neoplasms/surgery-
dc.subject.MESHRacemases and Epimerases/genetics*-
dc.subject.MESHRisk Factors-
dc.titleGenetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorSang-Jin Lee-
dc.contributor.googleauthorJae Young Joung-
dc.contributor.googleauthorHyekyoung Yoon-
dc.contributor.googleauthorJeong Eun Kim-
dc.contributor.googleauthorWeon Seo Park-
dc.contributor.googleauthorHo Kyung Seo-
dc.contributor.googleauthorJinsoo Chung-
dc.contributor.googleauthorJung-Ah Hwang-
dc.contributor.googleauthorSeung-Hyun Hong-
dc.contributor.googleauthorSeungyoon Nam-
dc.contributor.googleauthorSohee Park-
dc.contributor.googleauthorJeongseon Kim-
dc.contributor.googleauthorKang Hyun Lee-
dc.contributor.googleauthorYeon-Su Lee-
dc.identifier.doi10.1155/2013/394285-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01531-
dc.relation.journalcodeJ00315-
dc.identifier.eissn2314-6141-
dc.identifier.pmid24383053-
dc.subject.keywordAged-
dc.subject.keywordAlleles-
dc.subject.keywordAsian Continental Ancestry Group/genetics-
dc.subject.keywordGene Expression Regulation, Neoplastic-
dc.subject.keywordGenetic Association Studies*-
dc.subject.keywordGenetic Predisposition to Disease*-
dc.subject.keywordGenotype-
dc.subject.keywordHaplotypes-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordPolymorphism, Single Nucleotide-
dc.subject.keywordProstatectomy-
dc.subject.keywordProstatic Neoplasms/genetics*-
dc.subject.keywordProstatic Neoplasms/pathology-
dc.subject.keywordProstatic Neoplasms/surgery-
dc.subject.keywordRacemases and Epimerases/genetics*-
dc.subject.keywordRisk Factors-
dc.contributor.alternativeNamePark, So Hee-
dc.contributor.affiliatedAuthorPark, So Hee-
dc.rights.accessRightsfree-
dc.citation.volume2013-
dc.citation.startPage394285-
dc.identifier.bibliographicCitationBIOMED RESEARCH INTERNATIONAL, Vol.2013 : 394285, 2013-
dc.identifier.rimsid34420-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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