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Effects of endostatin and a new drug terpestacin against human neuroblastoma xenograft and cell lines

Authors
 Ki Cheong Park  ;  Seung Hoon Choi 
Citation
 PEDIATRIC SURGERY INTERNATIONAL, Vol.29(12) : 1327-1340, 2013 
Journal Title
 PEDIATRIC SURGERY INTERNATIONAL 
ISSN
 0179-0358 
Issue Date
2013
MeSH
Angiogenesis Inhibitors/pharmacology* ; Animals ; Bridged Bicyclo Compounds/pharmacology ; Cell Line ; Endostatins/pharmacology* ; Heterografts/drug effects* ; Humans ; Mice ; Neuroblastoma/drug therapy* ; Tumor Cells, Cultured
Keywords
Angiogenesis ; Metastasis ; Immunohistochemistry
Abstract
New development in the vascular network is a significant process for the proliferation, as well as metastatic expand, of cancer cells that depends on a sufficient provider of oxygen and nutrients and the removal of waste products. New blood and lymphatic vessels form via step called angiogenesis and lymphangiogenesis. Angiogenesis is controlled by activator and inhibitor of some molecules. So many different proteins have been established as angiogenic activators and inhibitors. Grades of expression of angiogenic factors demonstrate the forcefulness of tumor cells. The advance of angiogenic inhibitors should help to decrease both mortality and morbidity from carcinomas. So many patients have received anti-angiogenic therapy to date. Nevertheless, their notional efficacy and anti-angiogeic treatments have not demonstrated to be useful in terms of long-term survival. There is a crucial need for a new close treatment plan combining anti-angiogenic agents with standard cyto-reductive treatments in the regulation of cancer.
Full Text
http://link.springer.com/article/10.1007%2Fs00383-013-3398-1
DOI
10.1007/s00383-013-3398-1
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Ki Cheong(박기청) ORCID logo https://orcid.org/0000-0002-3435-3985
Choi, Seung Hoon(최승훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89117
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