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Liquid-based fine needle aspiration biopsy of papillary thyroid carcinoma: Logistic regression analysis with conventional and new cytomorphologic features

Authors
 Lee J.S.  ;  Choi H.-S.  ;  Park I.A.  ;  Ryu H.S. 
Citation
 ACTA CYTOLOGICA, Vol.57(3) : 233-240, 2013 
Journal Title
 ACTA CYTOLOGICA 
ISSN
 0001-5547 
Issue Date
2013
MeSH
Adenocarcinoma, Follicular/pathology* ; Adenoma/pathology* ; Adenoma, Oxyphilic ; Biopsy, Fine-Needle/methods* ; Carcinoma/pathology* ; Carcinoma, Papillary ; Chi-Square Distribution ; Decision Support Techniques* ; Diagnosis, Differential ; Humans ; Hyperplasia ; Logistic Models ; Multivariate Analysis ; Predictive Value of Tests ; Retrospective Studies ; Thyroid Neoplasms/pathology*
Keywords
Liquid-based cytology ; SurePath ; Fine needle aspiration ; Cytomorphology ; Papillary thyroid carcinoma
Abstract
OBJECTIVE: The morphological interpretation of liquid-based preparation (LBP) remains a diagnostic challenge due to altered cytomorphology with technical reason. Only a few published accounts of the cytopathological features needed for diagnosis of papillary thyroid carcinoma (PTC) on an LBP exist. We utilized the SurePath LBP system to evaluate conventional and newly recognized cytomorphologic features on histologically confirmed PTC to identify their potent diagnostic significance compared to benign follicular neoplasm (BFN). STUDY DESIGN: One-hundred and three cases of PTC and 84 BFNs were collected using preoperative fine needle aspiration biopsies. We evaluated and compared 16 cytomorphologic findings in PTC and BFN using an LBP. RESULTS: Among the conventional criteria, papillary structures, fewer background colloids and macrophages, hobnail patterns (54.4% in PTC vs. 10.7% in BFN; p < 0.001) and swirling architecture (14.6% in PTC vs. 0% in BFN; p < 0.001; positive predictive value 100.0%) were significant diagnostic findings for PTC compared to BFN. The hobnail pattern was shown as a newly recognized strong diagnostic parameter for PTC (odds ratio 50.157, p < 0.001). CONCLUSION: The identified distinctive cytological criteria may be helpful in cases where conventional criteria for PTC are insufficient. Furthermore, application of these findings, along with classical criteria, may enhance the diagnostic accuracy of PTC by fine needle aspiration biopsy.
Full Text
http://www.karger.com/Article/FullText/342989
DOI
10.1159/000342989
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Seok(이재석)
Choi, Heeseung(최희승)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89079
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