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Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans

DC FieldValueLanguage
dc.contributor.author박민수-
dc.contributor.author정재용-
dc.contributor.author조성권-
dc.contributor.author김춘옥-
dc.date.accessioned2014-12-18T09:54:48Z-
dc.date.available2014-12-18T09:54:48Z-
dc.date.issued2013-
dc.identifier.issn1347-4367-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89063-
dc.description.abstractPitavastatin, a 3-hydroxyl-3-methylglutaryl-coenzyme A reductase inhibitor is distributed to the liver, a target organ of action and excreted mainly into the bile. To investigate the impact of influx (OATP1B1) and efflux (MRP2, BCRP) transporter alleles on its disposition, the pharmacokinetic (PK) parameters were compared among the following groups: SLCO1B1 (*15 carrier and non-carrier), ABCC2 (G1249A, C3972T, C−24T, G1549A, and G1774T), and ABCG2 (C421A) single nucleotide polymorphisms in 45 healthy Korean volunteers. Pitavastatin AUClast was higher in individuals carrying the SLCO1B1*15 allele than those not carrying it (144.1 ± 55.3 vs. 84.7 ± 25.7 h·ng/mL [mean ± SD], p = 0.002). The AUClast varied significantly according to the ABCC2 C−24T allele (103.4 ± 42.2, 80.2 ± 23.8, and 39.0 h·ng/mL in CC, CT and TT, respectively; p = 0.027). Other SNPs of ABCC2 and ABCG2 were not significant. The effect of these transporters and body weight on the AUClast and Cmax were tested, and only SLCO1B1 and ABCC2 C−24T genotypes were significant factors by analysis of covariance. These variants accounted for almost 50% of the variation in AUClast and Cmax of pitavastatin. Therefore, ABCC2 C−24T was significantly associated with pitavastatin human PK when the known effect of SLCO1B1*15 was also considered.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfDRUG METABOLISM AND PHARMACOKINETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHATP Binding Cassette Transporter, Sub-Family G, Member 2-
dc.subject.MESHATP-Binding Cassette Transporters/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics*-
dc.subject.MESHMale-
dc.subject.MESHMultidrug Resistance-Associated Proteins/genetics*-
dc.subject.MESHNeoplasm Proteins/genetics*-
dc.subject.MESHOrganic Anion Transporters/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHQuinolines/pharmacokinetics*-
dc.subject.MESHSolute Carrier Organic Anion Transporter Family Member 1b1-
dc.titleImpact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorEun Sil OH-
dc.contributor.googleauthorChoon OK KIM-
dc.contributor.googleauthorSung Kweon CHO-
dc.contributor.googleauthorMin Soo PARK-
dc.contributor.googleauthorJae-Yong CHUNG-
dc.identifier.doi10.2133/dmpk.DMPK-12-RG-068-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01468-
dc.contributor.localIdA03709-
dc.contributor.localIdA03829-
dc.contributor.localIdA04735-
dc.relation.journalcodeJ00750-
dc.identifier.eissn1880-0920-
dc.identifier.pmid23007012-
dc.subject.keywordpitavastatin-
dc.subject.keywordMRP2-
dc.subject.keywordBCRP-
dc.subject.keywordOATP1B1-
dc.subject.keywordpharmacokinetic-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameChung, Jae Yong-
dc.contributor.alternativeNameCho, Sung Kweon-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorChung, Jae Yong-
dc.contributor.affiliatedAuthorCho, Sung Kweon-
dc.rights.accessRightsfree-
dc.citation.volume28-
dc.citation.number3-
dc.citation.startPage196-
dc.citation.endPage202-
dc.identifier.bibliographicCitationDRUG METABOLISM AND PHARMACOKINETICS, Vol.28(3) : 196-202, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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