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Laparoscopic gastrectomy for advanced gastric cancer: Are the long-term results comparable with conventional open gastrectomy? A systematic review and meta-analysis

Authors
 Yoon Young Choi  ;  Jung Min Bae  ;  Ji Yeong An  ;  Woo Jin Hyung  ;  Sung Hoon Noh 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.108(8) : 550-556, 2013 
Journal Title
 JOURNAL OF SURGICAL ONCOLOGY 
ISSN
 0022-4790 
Issue Date
2013
MeSH
Adult ; Aged ; Female ; Gastrectomy/adverse effects ; Gastrectomy/methods* ; Gastrectomy/mortality ; Humans ; Kaplan-Meier Estimate ; Laparoscopy* ; Lymph Node Excision ; Male ; Middle Aged ; Observer Variation ; Stomach Neoplasms/mortality ; Stomach Neoplasms/surgery* ; Treatment Outcome
Keywords
laparoscopy ; minimally invasive surgery ; gastric cancer ; prognosis ; meta‐analysis
Abstract
BACKGROUND AND OBJECTIVE: Laparoscopic gastrectomy (LG) for gastric cancer has been adopted to treat both early and locally advanced gastric cancer (AGC), but there are still concerns about its oncologic safety especially in AGC. The purpose of this meta-analysis is to compare the long-term outcomes of LG with those of open gastrectomy (OG) in patients with AGC. METHODS: The quantitative synthesis of outcomes of studies from three major databases, PubMed, Embase, and the Cochrane Central, was performed using common keywords related to gastric cancer and laparoscopy on July 31, 2012. RESULTS: Ten studies (one randomized controlled trial and nine retrospective cohort studies) with 1,819 participants (960 patients in OG, and 859 patients in LG) were included in the current meta-analysis. Nine studies compared the overall survival rate between LG and OG for AGC, and five studies reported the disease-free survival. There was no statistical difference in overall survival (hazard ratio [HR]: 0.90, 95% confidence interval [CI]: 0.76-1.06, P = 0.22) and disease-free survival (HR: 1.03, 95% CI: 0.76-1.40, P = 0.86) between the two modalities. CONCLUSIONS: The current clinical evidence revealed that there was no evidence that LG is inferior to OG even for AGC if the surgeons have sufficient experience.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.23438/abstract
DOI
10.1002/jso.23438
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Choi, Yoon Young(최윤영) ORCID logo https://orcid.org/0000-0002-2179-7851
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89050
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