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Role of radiotherapy for pancreatobiliary neuroendocrine tumors

Authors
 Jeongshim Lee  ;  Jinhyun Choi  ;  Chihwan Choi  ;  Jinsil Seong 
Citation
 RADIATION ONCOLOGY JOURNAL, Vol.31(3) : 125-130, 2013 
Journal Title
RADIATION ONCOLOGY JOURNAL
ISSN
 2234-1900 
Issue Date
2013
Keywords
Neuroendocrine tumors ; Radiotherapy ; Treatment outcome
Abstract
PURPOSE: We investigated the role of radiotherapy (RT) for pancreatobiliary neuroendocrine tumors (PB-NETs). MATERIALS AND METHODS: We identified 9 patients with PB-NETs who received RT between January 2005 and March 2012. Of these 9 patients, 4 were diagnosed with NETs in the pancreas and 5 were diagnosed with NETs in the gallbladder. All patients received RT to the primary tumor or resection bed with a median total irradiation dose of 50.4 Gy, with or without chemotherapy. RESULTS: The tumor response rate and tumor control rate in the RT field were 60% and 100 %, respectively. All 4 patients who underwent surgery had no evidence of disease in the RT field. Of the 5 patients who received RT to the primary gross tumor, 1 had complete response, 2 had partial response, and 2 had stable disease in the RT field. The median time to progression was 11 months. Of the 9 patients, four patients had no progression, and 5 patients had progression of disease (locoregional, 2; distant, 2; locoregional/distant, 1). Of the 4 patients without progression, 3 were treated with RT in adjuvant or neoadjuvant setting, and one received RT to primary tumor. One patient experienced radiation-induced duodenitis at 3 months after concurrent chemoradiation without treatment-related mortality. CONCLUSION: RT can yield local control for advanced PB-NETs. RT should be considered an essential part of multimodality treatment in management of advanced PB-NETs.
Files in This Item:
T201305436.pdf Download
DOI
10.3857/roj.2013.31.3.125
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Choi, Chi Hwan(최치환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88999
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