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Prognostic Value of Metabolic Activity Measured by 18F-FDG PET/CT in Patients with Advanced Endometrial Cancer

Authors
 Hyun Jeong Kim  ;  Jiyoun Choi  ;  Yong Hyu Jeong  ;  Kwan Hyeong Jo  ;  Jae-Hoon Lee  ;  Arthur Cho  ;  Mijin Yun  ;  Jong Doo Lee  ;  Young Tae Kim  ;  Won Jun Kang 
Citation
 Nuclear Medicine and Molecular Imaging (핵의학 분자영상), Vol.47(4) : 257-262, 2013 
Journal Title
 Nuclear Medicine and Molecular Imaging  (핵의학 분자영상) 
ISSN
 1869-3474 
Issue Date
2013
Abstract
Purpose We evaluated the potential prognostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with stage IIIC/IV endometrial cancer. Methods Patients with stage IIIC/IV endometrial cancer who had undergone FDG PET/CT workup for staging were enrolled. Maximum standardized uptake values (SUVmax) measured from regions of interest (ROIs) of the primary tumor (SUVt) and lymph nodes (SUVn) were correlated with overall survival (OS). The SUVn was defined as the highest SUVmax of the metastatic lymph nodes. Survival probability was assessed using the Kaplan-Meier method. Results A total of 42 patients with a median age of 55.5 years (range 32–76 years) were included. Twenty-nine percent (n = 12) of patients were premenopausal and 71 % (n = 30) were postmenopausal. The average SUVt was 12.9 (range 1.8–36.5), and the average SUVn was 7.3 (range 2.0–22.5). Median follow-up time was 25.9 months (range 1–84 months). Using a SUVt of 9.5 as a cutoff value, two groups with different rates were determined (P = 0.026). In addition, patients with a low SUVn had significantly better OS than those with a high SUVn (P = 0.003). Patients in the International Federation of Obstetrics and Gynecology (FIGO) stage IV group with SUVt ≥ 9.5 or SUVn ≥ 7.3 showed a significantly longer OS than the other groups. Conclusions FDG uptake of primary endometrial cancer and lymph nodes might be a prognostic factor in advanced endometrial cancer. More aggressive therapy could be considered in patients with stage IV endometrial cancer and high SUVt and/or high SUVn.
Full Text
http://link.springer.com/article/10.1007%2Fs13139-013-0228-2
DOI
10.1007/s13139-013-0228-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
강원준(Kang, Won Jun) ORCID logo https://orcid.org/0000-0002-2107-8160
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이재훈(Lee, Jae Hoon) ORCID logo https://orcid.org/0000-0002-9898-9886
이종두(Lee, Jong Doo)
정용휴(Jeong, Yong Hyu) ORCID logo https://orcid.org/0000-0002-0198-0026
조응혁(Cho, Arthur Eung Hyuck) ORCID logo https://orcid.org/0000-0001-8670-2473
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88850
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