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Detection of the inflammatory process in a Behçet's disease-like mouse model using 18F-fluorodeoxyglucose positron emission tomography

 S. Cho  ;  S. Sohn  ;  Z. Zheng  ;  A. Cho  ;  H. Kim  ;  W. Kang  ;  D. Bang  ;  M. Yun  ;  J. Lee  ;  J. Lee 
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.31(3 suppl.77) : 47-53, 2013 
Journal Title
Issue Date
Animals ; Behcet Syndrome/diagnostic imaging* ; Behcet Syndrome/immunology ; Behcet Syndrome/pathology ; Behcet Syndrome/virology ; Disease Models, Animal ; Fluorodeoxyglucose F18* ; Herpes Simplex/diagnostic imaging* ; Herpes Simplex/immunology ; Herpes Simplex/pathology ; Herpes Simplex/virology ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/pathogenicity ; Inflammation/diagnostic imaging* ; Inflammation/immunology ; Inflammation/pathology ; Inflammation/virology ; Joints/diagnostic imaging* ; Joints/immunology ; Joints/pathology ; Joints/virology ; Male ; Mice ; Mice, Inbred ICR ; Positron-Emission Tomography* ; Predictive Value of Tests ; Radiopharmaceuticals*
Behçet’s disease ; 18F-fluorodeoxyglucose positron emission tomography ; Behçet’s disease-like mouse model ; inflammation
OBJECTIVES: The major role of herpes simplex virus (HSV) type 1 infection in Behçet's disease (BD) immunopathogenesis has been demonstrated and inoculating the earlobes of ICR mice with HSV produced a BD-like mouse model. (18)Ffluorodeoxyglucose positron emission tomography (FDG PET) is widely used for diagnosing numerous human diseases other than malignancies. The aim of our study was to evaluate the inflammatory activities of BD-like symptoms in a HSV type 1-induced BD-like mouse model by small-animal FDG PET. METHODS: Five HSV-infected ICR mice with BD-like lesions, two asymptomatic HSV-infected mice, and two untreated mice were scanned with microPET, and autopsy specimens were histopathologically assessed to evaluate for infiltration by mixed inflammatory cells. RESULTS: The histopathological evaluation of the inflammatory process in knee and elbow joints significantly correlated with the quantitative assessment of FDG accumulation in the same joints in BD-like ICR mice, HSV-infected asymptomatic mice, and untreated control mice. Small-animal FDG PET clearly detected asymptomatic joint inflammatory processes in both BD-like mice and HSV-infected asymptomatic mice. In addition, genital ulcers and skin ulcers with associated perilesional lymphadenopathies in BD-like models were detected by microPET. However, biodistributed PET-positive images from the stasis of secreted FDG into the bowel lumen could not be distinguished from the inflammatory bowel lesions of BD when compared to FDG uptake in control mice. CONCLUSIONS: Our data indicate that FDG PET can non-invasively and quantitatively detect the inflammatory process in an HSV-induced BD-like mouse model.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Won Jun(강원준) ORCID logo https://orcid.org/0000-0002-2107-8160
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Bang, Dong Sik(방동식)
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Jong Doo(이종두)
Zheng, Zhen Long(정진룡)
Cho, Sung Bin(조성빈)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
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