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Improvement of type 2 diabetes mellitus after gastric cancer surgery: short-term outcome analysis after gastrectomy.

Authors
 Ji Yeong An  ;  Yoo Min Kim  ;  Min Ah Yun  ;  Byeong Hee Jeon  ;  Sung Hoon Noh 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.19(48) : 9410-9417, 2013 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2013
MeSH
Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Chi-Square Distribution ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/diagnosis ; Duodenostomy ; Fasting/blood ; Female ; Gastrectomy* ; Gastric Bypass ; Glycated Hemoglobin A/metabolism ; Humans ; Insulin/blood ; Insulin Resistance ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prospective Studies ; Stomach Neoplasms/complications ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery* ; Time Factors ; Treatment Outcome
Keywords
Gastrectomy ; Gastric cancer ; Glucose control ; Short-term outcome ; Type 2 diabetes mellitus
Abstract
AIM: To evaluate the effect of gastrectomy on diabetes control in patients with type 2 diabetes mellitus and early gastric cancer. METHODS: Data from 64 patients with early gastric cancer and type 2 diabetes mellitus were prospectively collected. All patients underwent curative gastrectomy (36 subtotal gastrectomy with gastroduodenostomy, 16 subtotal gastrectomy with gastrojejunostomy, 12 total gastrectomy) and their physical and laboratory data were evaluated before and 3, 6 and 12 mo after surgery. RESULTS: Fasting blood glucose (FBS), HbA1c, insulin, C-peptide, and homeostasis model assessment-estimated insulin resistance were significantly improved 3 mo after surgery, regardless of operation type, and the significant improvement in all measured values, except HbA1c, was sustained up to 12 mo postoperatively. Approximately 3.1% of patients stopped diabetes medication and had HbA1c < 6.0% and FBS < 126 mg/dL. 54.7% of patients decreased their medication, and had reduced FBS or HbA1c. In multivariate analysis, good diabetic control was not associated with operation type, but was associated with diabetes duration. CONCLUSION: Diabetes improved in more than 50% of patients during the first year after gastric cancer surgery. The degree of diabetes control was related to diabetes duration.
Files in This Item:
T201304866.pdf Download
DOI
10.3748/wjg.v19.i48.9410
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88775
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