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Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer

 Joon-Yong Chung  ;  Haruhisa Kitano  ;  Mikiko Takikita  ;  Hanbyoul Cho  ;  Kyung Hee Noh  ;  Tae Woo Kim  ;  Kris Ylaya  ;  Jun Hanaoka  ;  Junya Fukuoka  ;  Stephen M. Hewitt 
 HUMAN PATHOLOGY, Vol.44(4) : 472-479, 2013 
Journal Title
Issue Date
Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cytoplasm/metabolism ; Cytoplasm/pathology ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism* ; Lung Neoplasms/mortality ; Lymphatic Metastasis/pathology ; Male ; Neoplasm Invasiveness ; Neoplasm Staging ; Nuclear Proteins/metabolism* ; Pleura/pathology ; Pneumonectomy ; Prognosis ; Survival Rate ; Synaptonemal Complex/metabolism* ; Synaptonemal Complex/pathology ; Tissue Array Analysis
Immunohistochemistry ; Non–small cell lung cancer ; Prognostic marker ; Synaptonemal complex protein 3 ; Tissue microarray
Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
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