Cited 26 times in
Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2014-12-18T09:44:29Z | - |
dc.date.available | 2014-12-18T09:44:29Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88739 | - |
dc.description.abstract | Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HUMAN PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/metabolism* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/mortality | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/secondary | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Nucleus/metabolism | - |
dc.subject.MESH | Cell Nucleus/pathology | - |
dc.subject.MESH | Cytoplasm/metabolism | - |
dc.subject.MESH | Cytoplasm/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/diagnosis | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Lung Neoplasms/mortality | - |
dc.subject.MESH | Lymphatic Metastasis/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Nuclear Proteins/metabolism* | - |
dc.subject.MESH | Pleura/pathology | - |
dc.subject.MESH | Pneumonectomy | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Synaptonemal Complex/metabolism* | - |
dc.subject.MESH | Synaptonemal Complex/pathology | - |
dc.subject.MESH | Tissue Array Analysis | - |
dc.title | Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Haruhisa Kitano | - |
dc.contributor.googleauthor | Mikiko Takikita | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Kyung Hee Noh | - |
dc.contributor.googleauthor | Tae Woo Kim | - |
dc.contributor.googleauthor | Kris Ylaya | - |
dc.contributor.googleauthor | Jun Hanaoka | - |
dc.contributor.googleauthor | Junya Fukuoka | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.identifier.doi | 10.1016/j.humpath.2012.06.018 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J01011 | - |
dc.identifier.eissn | 1532-8392 | - |
dc.identifier.pmid | 23069255 | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Non–small cell lung cancer | - |
dc.subject.keyword | Prognostic marker | - |
dc.subject.keyword | Synaptonemal complex protein 3 | - |
dc.subject.keyword | Tissue microarray | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 472 | - |
dc.citation.endPage | 479 | - |
dc.identifier.bibliographicCitation | HUMAN PATHOLOGY, Vol.44(4) : 472-479, 2013 | - |
dc.identifier.rimsid | 33583 | - |
dc.type.rims | ART | - |
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