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An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock.

 Chan Ho Kim  ;  Jung Tak Park  ;  Eun Jin Kim  ;  Jae Hyun Han  ;  Ji Suk Han  ;  Jun Yong Choi  ;  Seung Hyeok Han  ;  Tae-Hyun Yoo  ;  Young Sam Kim  ;  Shin-Wook Kang  ;  Hyung Jung Oh 
 CRITICAL CARE, Vol.17(6) : 282, 2013 
Journal Title
Issue Date
Aged ; Cause of Death ; Erythrocyte Indices* ; Female ; Hospital Mortality* ; Hospitalization ; Humans ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Sepsis/blood* ; Sepsis/mortality* ; Shock, Septic/blood* ; Shock, Septic/mortality* ; Time Factors
Septic Shock ; Severe Sepsis ; Renal Replacement Therapy ; Sequential Organ Failure Assessment ; Charlson Comorbidity Index
INTRODUCTION: A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although the mechanism underlying this relationship remains unclear. Little is known about the impact changes in RDW may have on survival in critically ill patients. Therefore, we investigated the prognostic significance of changes in RDW during hospital stay in patients with severe sepsis or septic shock. METHODS: We prospectively enrolled 329 patients who were admitted to the emergency department (ED) and received a standardized resuscitation algorithm (early-goal directed therapy) for severe sepsis or septic shock. The relationship between the changes in RDW during the first 72 hours after ED admission and all-cause mortality (28-day and 90-day) were analyzed by categorizing the patients into four groups according to baseline RDW value and ΔRDW72hr-adm (RDW at 72 hours - RDW at baseline). RESULTS: The 28-day and 90-day mortality rates were 10% and 14.6%, respectively. Patients with increased RDW at baseline and ΔRDW72hr-adm >0.2% exhibited the highest risks of 28-day and 90-day mortality, whereas the patients with normal RDW level at baseline and ΔRDW72hr-adm ≤0.2% (the reference group) had the lowest mortality risks. For 90-day mortality, a significantly higher mortality risk was observed in the patients whose RDW increased within 72 hours of ED admission (normal RDW at baseline and ΔRDW72hr-adm >0.2%), compared to the reference group. These associations remained unaltered even after adjusting for age, sex, Sequential Organ Failure Assessment (SOFA) score, Charlson Comorbidity Index, renal replacement therapy, albumin, hemoglobin, lactate, C-reactive protein and infection sites in multivariable models. CONCLUSIONS: We found that an increase in RDW from baseline during the first 72 hours after hospitalization is significantly associated with adverse clinical outcomes. Therefore, a combination of baseline RDW value and an increase in RDW can be a promising independent prognostic marker in patients with severe sepsis or septic shock.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Kim, Eun Jin(김은진)
Kim, Chan Ho(김찬호)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Oh, Hyung Jung(오형중)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
Han, Jae Hyun(한재현)
Hahn, Jee Sook(한지숙)
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