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Graft Function Measured by Transient Elastography in Living Donor Liver Transplantation: Preliminary

Authors
 S.H. Lee  ;  D.J. Joo  ;  S.U. Kim  ;  M.S. Kim  ;  A.-L. Lee  ;  G.H. Choi  ;  J.S. Choi  ;  K.H. Han  ;  S.I. Kim 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.45(8) : 3028-3031, 2013 
Journal Title
 TRANSPLANTATION PROCEEDINGS 
ISSN
 0041-1345 
Issue Date
2013
MeSH
Bilirubin/blood ; Elasticity Imaging Techniques ; Female ; Graft Survival* ; Humans ; International Normalized Ratio ; Liver Transplantation* ; Living Donors* ; Male ; Middle Aged ; Retrospective Studies ; Tomography, X-Ray Computed
Keywords
Bilirubin/blood ; Elasticity Imaging Techniques ; Female ; Graft Survival* ; Humans ; International Normalized Ratio ; Liver Transplantation* ; Living Donors* ; Male ; Middle Aged ; Retrospective Studies ; Tomography, X-Ray Computed
Abstract
INTRODUCTION: Liver stiffness measurements (LSMs) using transient elastography (TE) provide a noninvasive means to assess liver fibrosis that correlate with hepatic cholestasis. However, few studies have examined the correlation of TE to obtain LSMs with perioperative clinical and laboratory parameters in living donor liver transplantation (LDLT). PATIENTS AND METHODS: We retrospectively reviewed forty-eight subjects who underwent LDLT between November 2010 and October 2012. All donors and recipients underwent TE, abdominal computed tomography (CT), and biochemical tests within 1 month before and at 1 week after transplantation. Using a cut-off LSM of 7.5 kPa, which we arbitrarily assigned to be indicative of significant fibrosis, we divided our study population into ≤7.5 kPa (group L; n = 15, 31.3%) versus >7.5 kPa; (group H; n = 33, 68.8%). RESULTS: Pretransplantation serum total bilirubin, international normalized ratio, and Model for End-stage Liver Disease scores of recipients were significantly higher in group H than group L. Regarding the pretransplantation donor characteristics, the graft-recipient weight ratio was significantly smaller among those in group H (P = .039). In addition, the post-transplantation 1-week serum total bilirubin level was significantly higher in group H (2.3 mg/dL versus 1.2 mg/dL, P = .015), although neither biliary complications norhepatic congestion was identified by abdominal CT. Among the 1-week post-transplantation laboratory findings, only total bilirubin positively correlated with LSM (P = .044). CONCLUSIONS: This pilot study suggested that a high LSM after LDLT suggests intrahepatic cholestasis and portal hypercirculation in the graft, irrespective of liver fibrosis, outflow obstruction, or biliary obstruction.
Full Text
http://www.sciencedirect.com/science/article/pii/S004113451300794X
DOI
10.1016/j.transproceed.2013.08.051
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Lee, Su Hyung(이수형)
Lee, A Lan(이아란)
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88677
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