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Immune response after systematic lymph node dissection in lung cancer surgery: changes of interleukin-6 level in serum, pleural lavage fluid, and lung supernatant in a dog model

 Seong Yong Park  ;  Dae Joon Kim  ;  Abdullah Aldohayan  ;  Iftikhar Ahmed  ;  Sufia Husain  ;  Ammar Al Rikabi  ;  Abdulazeem Aldawlatly  ;  Omar Al Obied  ;  Waseem Hajjar  ;  Sami Al Nassar 
 World Journal of Surgical Oncology, Vol.11 : 270, 2013 
Journal Title
 World Journal of Surgical Oncology 
Issue Date
Animals ; Biomarkers/analysis* ; Bronchoalveolar Lavage Fluid/chemistry* ; Disease Models, Animal ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Immunoenzyme Techniques ; Inflammation/diagnosis* ; Inflammation/immunology ; Inflammation/metabolism ; Interleukin-6/blood* ; Lung Neoplasms/blood ; Lung Neoplasms/surgery* ; Lymph Node Excision* ; Thoracotomy
IL-6 ; Lung cancer ; Mediastinal lymph node dissection
BACKGROUND: Systematic nodal dissection (SND) is regarded as a core component of lung cancer surgery. However, there has been a concern on the increased morbidity associated with SND. This study was performed to investigate whether or not SND induces significant immune response. METHODS: Sixteen dogs were divided into two groups; group 1 (n = 8) underwent thoracotomy only, and group 2 (n = 8) underwent SND after thoracotomy. We compared interleukin-6 (IL-6) levels in serum, pleural lavage fluid and lung supernatant at the time of thoracotomy (T0) and at 2 h(T1) after thoracotomy (group 1) or SND (group 2). Severity of inflammation and IL-6 expression in lung tissue were evaluated in a semi-quantitative manner. RESULTS: The operative results were comparable. IL-6 was not detected in serum in either group. IL-6 in pleural lavage fluid marginally increased from 4.75 ± 3.74 pg/mL at T0 to 19.75 ± 8.67 pg/mL at T1 in group 1 (P = 0.112), and from 7.75 ± 5.35 pg/mL to 17.72 ± 8.58 pg/mL in group 2 (P = 0.068). IL-6 in lung supernatant increased from 0.36 ± 0.14 pg/mL/mg to 1.15 ± 0.17 pg/mL/mg in group 1 (P = 0.003), and from 0.25 ± 0.08 pg/mL/mg to 0.82 ± 0.17 pg/mL/mg in group 2 (P = 0.001). However, the degree of increase in IL-6 in pleural lavage fluid and lung supernatant were not different between two groups (P = 0.421 and P = 0.448). There was no difference in severity of inflammation and IL-6 expression between groups. CONCLUSIONS: SND did not increase IL-6 in pleural lavage fluid and lung supernatant. This result suggests that SND could be routinely performed in lung cancer surgery without increasing the significant inflammatory response.
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1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Park, Seong Yong(박성용)
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