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Immune response after systematic lymph node dissection in lung cancer surgery: changes of interleukin-6 level in serum, pleural lavage fluid, and lung supernatant in a dog model

DC Field Value Language
dc.contributor.author김대준-
dc.contributor.author박성용-
dc.date.accessioned2014-12-18T09:42:05Z-
dc.date.available2014-12-18T09:42:05Z-
dc.date.issued2013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88663-
dc.description.abstractBACKGROUND: Systematic nodal dissection (SND) is regarded as a core component of lung cancer surgery. However, there has been a concern on the increased morbidity associated with SND. This study was performed to investigate whether or not SND induces significant immune response. METHODS: Sixteen dogs were divided into two groups; group 1 (n = 8) underwent thoracotomy only, and group 2 (n = 8) underwent SND after thoracotomy. We compared interleukin-6 (IL-6) levels in serum, pleural lavage fluid and lung supernatant at the time of thoracotomy (T0) and at 2 h(T1) after thoracotomy (group 1) or SND (group 2). Severity of inflammation and IL-6 expression in lung tissue were evaluated in a semi-quantitative manner. RESULTS: The operative results were comparable. IL-6 was not detected in serum in either group. IL-6 in pleural lavage fluid marginally increased from 4.75 ± 3.74 pg/mL at T0 to 19.75 ± 8.67 pg/mL at T1 in group 1 (P = 0.112), and from 7.75 ± 5.35 pg/mL to 17.72 ± 8.58 pg/mL in group 2 (P = 0.068). IL-6 in lung supernatant increased from 0.36 ± 0.14 pg/mL/mg to 1.15 ± 0.17 pg/mL/mg in group 1 (P = 0.003), and from 0.25 ± 0.08 pg/mL/mg to 0.82 ± 0.17 pg/mL/mg in group 2 (P = 0.001). However, the degree of increase in IL-6 in pleural lavage fluid and lung supernatant were not different between two groups (P = 0.421 and P = 0.448). There was no difference in severity of inflammation and IL-6 expression between groups. CONCLUSIONS: SND did not increase IL-6 in pleural lavage fluid and lung supernatant. This result suggests that SND could be routinely performed in lung cancer surgery without increasing the significant inflammatory response.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfWORLD JOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBiomarkers/analysis*-
dc.subject.MESHBronchoalveolar Lavage Fluid/chemistry*-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDogs-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHInflammation/diagnosis*-
dc.subject.MESHInflammation/immunology-
dc.subject.MESHInflammation/metabolism-
dc.subject.MESHInterleukin-6/blood*-
dc.subject.MESHLung Neoplasms/blood-
dc.subject.MESHLung Neoplasms/surgery*-
dc.subject.MESHLymph Node Excision*-
dc.subject.MESHThoracotomy-
dc.titleImmune response after systematic lymph node dissection in lung cancer surgery: changes of interleukin-6 level in serum, pleural lavage fluid, and lung supernatant in a dog model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorAbdullah Aldohayan-
dc.contributor.googleauthorIftikhar Ahmed-
dc.contributor.googleauthorSufia Husain-
dc.contributor.googleauthorAmmar Al Rikabi-
dc.contributor.googleauthorAbdulazeem Aldawlatly-
dc.contributor.googleauthorOmar Al Obied-
dc.contributor.googleauthorWaseem Hajjar-
dc.contributor.googleauthorSami Al Nassar-
dc.identifier.doi10.1186/1477-7819-11-270-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00368-
dc.contributor.localIdA01508-
dc.relation.journalcodeJ02803-
dc.identifier.eissn1477-7819-
dc.identifier.pmid24112247-
dc.subject.keywordIL-6-
dc.subject.keywordLung cancer-
dc.subject.keywordMediastinal lymph node dissection-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNamePark, Seong Yong-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorPark, Seong Yong-
dc.rights.accessRightsfree-
dc.citation.volume11-
dc.citation.startPage270-
dc.identifier.bibliographicCitationWORLD JOURNAL OF SURGICAL ONCOLOGY, Vol.11 : 270, 2013-
dc.identifier.rimsid33392-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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