Cited 3 times in
Immune response after systematic lymph node dissection in lung cancer surgery: changes of interleukin-6 level in serum, pleural lavage fluid, and lung supernatant in a dog model
DC Field | Value | Language |
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dc.contributor.author | 김대준 | - |
dc.contributor.author | 박성용 | - |
dc.date.accessioned | 2014-12-18T09:42:05Z | - |
dc.date.available | 2014-12-18T09:42:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88663 | - |
dc.description.abstract | BACKGROUND: Systematic nodal dissection (SND) is regarded as a core component of lung cancer surgery. However, there has been a concern on the increased morbidity associated with SND. This study was performed to investigate whether or not SND induces significant immune response. METHODS: Sixteen dogs were divided into two groups; group 1 (n = 8) underwent thoracotomy only, and group 2 (n = 8) underwent SND after thoracotomy. We compared interleukin-6 (IL-6) levels in serum, pleural lavage fluid and lung supernatant at the time of thoracotomy (T0) and at 2 h(T1) after thoracotomy (group 1) or SND (group 2). Severity of inflammation and IL-6 expression in lung tissue were evaluated in a semi-quantitative manner. RESULTS: The operative results were comparable. IL-6 was not detected in serum in either group. IL-6 in pleural lavage fluid marginally increased from 4.75 ± 3.74 pg/mL at T0 to 19.75 ± 8.67 pg/mL at T1 in group 1 (P = 0.112), and from 7.75 ± 5.35 pg/mL to 17.72 ± 8.58 pg/mL in group 2 (P = 0.068). IL-6 in lung supernatant increased from 0.36 ± 0.14 pg/mL/mg to 1.15 ± 0.17 pg/mL/mg in group 1 (P = 0.003), and from 0.25 ± 0.08 pg/mL/mg to 0.82 ± 0.17 pg/mL/mg in group 2 (P = 0.001). However, the degree of increase in IL-6 in pleural lavage fluid and lung supernatant were not different between two groups (P = 0.421 and P = 0.448). There was no difference in severity of inflammation and IL-6 expression between groups. CONCLUSIONS: SND did not increase IL-6 in pleural lavage fluid and lung supernatant. This result suggests that SND could be routinely performed in lung cancer surgery without increasing the significant inflammatory response. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | WORLD JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers/analysis* | - |
dc.subject.MESH | Bronchoalveolar Lavage Fluid/chemistry* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Immunoenzyme Techniques | - |
dc.subject.MESH | Inflammation/diagnosis* | - |
dc.subject.MESH | Inflammation/immunology | - |
dc.subject.MESH | Inflammation/metabolism | - |
dc.subject.MESH | Interleukin-6/blood* | - |
dc.subject.MESH | Lung Neoplasms/blood | - |
dc.subject.MESH | Lung Neoplasms/surgery* | - |
dc.subject.MESH | Lymph Node Excision* | - |
dc.subject.MESH | Thoracotomy | - |
dc.title | Immune response after systematic lymph node dissection in lung cancer surgery: changes of interleukin-6 level in serum, pleural lavage fluid, and lung supernatant in a dog model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Seong Yong Park | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Abdullah Aldohayan | - |
dc.contributor.googleauthor | Iftikhar Ahmed | - |
dc.contributor.googleauthor | Sufia Husain | - |
dc.contributor.googleauthor | Ammar Al Rikabi | - |
dc.contributor.googleauthor | Abdulazeem Aldawlatly | - |
dc.contributor.googleauthor | Omar Al Obied | - |
dc.contributor.googleauthor | Waseem Hajjar | - |
dc.contributor.googleauthor | Sami Al Nassar | - |
dc.identifier.doi | 10.1186/1477-7819-11-270 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A01508 | - |
dc.relation.journalcode | J02803 | - |
dc.identifier.eissn | 1477-7819 | - |
dc.identifier.pmid | 24112247 | - |
dc.subject.keyword | IL-6 | - |
dc.subject.keyword | Lung cancer | - |
dc.subject.keyword | Mediastinal lymph node dissection | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Park, Seong Yong | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Park, Seong Yong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 270 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF SURGICAL ONCOLOGY, Vol.11 : 270, 2013 | - |
dc.identifier.rimsid | 33392 | - |
dc.type.rims | ART | - |
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