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Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis.

Authors
 Yoon Kang  ;  Hee-Jin Park  ;  Mi-I Kang  ;  Hyang-Sun Lee  ;  Sang-Won Lee  ;  Soo-Kon Lee  ;  Yong-Beom Park 
Citation
 ARTHRITIS RESEARCH & THERAPY, Vol.15(6) : 194, 2013 
Journal Title
 ARTHRITIS RESEARCH & THERAPY 
ISSN
 1478-6354 
Issue Date
2013
MeSH
Adipokines/blood* ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/complications* ; Arthritis, Rheumatoid/pathology ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/complications* ; Carotid Artery Diseases/diagnostic imaging ; Carotid Intima-Media Thickness ; Female ; Humans ; Inflammation/blood ; Inflammation/complications* ; Insulin Resistance* ; Male ; Middle Aged ; Risk Factors
Keywords
Rheumatoid Arthritis ; Insulin Resistance ; Waist Circumference ; Rheumatoid Arthritis Patient ; Common Carotid Artery
Abstract
INTRODUCTION: Cardiovascular (CV) morbidity and mortality are increased in patients with rheumatoid arthritis (RA). Inflammation is thought to be an important factor in accelerated atherosclerosis in RA, whereas insulin resistance is a known risk factor for atherosclerosis in RA. We hypothesised that adipokines could be a link between inflammation, insulin resistance, and atherosclerosis in RA. METHODS: The common carotid artery (CCA) intima-media thickness (IMT), CCA resistive index (RI), and carotid plaques were measured by ultrasonography in 192 patients with RA. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). Serum adiponectin, leptin, resistin, tumor necrosis factor-α, and interleukin (IL)-6 concentrations were determined. RESULTS: The CCA RI was associated with CCA IMT and the estimated total plaque volume after adjustment for conventional CV risk factors. Among adipokines, resistin and IL-6 were correlated with inflammatory parameters. Leptin and leptin:adiponectin (L:A) ratio were correlated with metabolic risk factors, including HOMA-IR. And L:A ratio was related to the CCA RI after adjustment for conventional and nonconventional CV risk factors, including HOMA-IR, erythrocyte sedimentation rate and C-reactive protein. CONCLUSION: L:A ratio was associated with HOMA-IR and carotid RI. L:A ratio might be an independent factor for predicting cardiovascular risk in patients with RA.
Full Text
http://arthritis-research.com/content/15/6/R194
DOI
10.1186/ar4384
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Mi Il(강미일)
Kang, Yoon(강윤)
Park, Yong Beom(박용범)
Park, Hee Jin(박희진)
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Lee, Soo Kon(이수곤)
Lee, Hyang Sun(이향선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88619
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