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Adiponectin as a new paradigm for approaching Alzheimer's disease

Authors
 Juhyun Song ; Jong Eun Lee 
Citation
 Anatomy and Cell Biology, Vol.46(4) : 229~234, 2013 
Journal Title
 Anatomy and Cell Biology 
ISSN
 2093-3665 
Issue Date
2013
Abstract
Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer's disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Previous studies demonstrated that adiponectin modulates memory and cognitive impairment and contributes to the deregulated glucose metabolism and mitochondrial dysfunction observed in Alzheimer's disease. Here, we aim to summarize recent studies that suggest the potential correlation between adiponectin and Alzheimer's disease.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/88599
DOI
10.5115/acb.2013.46.4.229
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
Yonsei Authors
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