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Cited 19 times in

Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study

DC Field Value Language
dc.contributor.author이지원-
dc.contributor.author이향규-
dc.contributor.author추상희-
dc.date.accessioned2014-12-18T09:39:08Z-
dc.date.available2014-12-18T09:39:08Z-
dc.date.issued2013-
dc.identifier.issn0918-8959-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88572-
dc.description.abstractSirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene expression in circulating peripheral blood mononuclear cells (PBMCs) and abdominal visceral adiposity as measured by computed tomography. We recruited 43 men and women without history of diabetes or cardiovascular disease Biomarkers of metabolic disease and body composition by computed tomography were assessed. SIRT1 gene expression was determined using isolated PBMCs. SIRT1 expression levels negatively correlated with body mass index, waist circumference, abdominal visceral fat area, and homeostasis model of assessment of insulin resistance (HOMA-IR) and positively correlated with adiponectin levels. Results of step-wise multiple regression analysis revealed that abdominal visceral fat area and HOMA-IR were independently associated with SIRT1 expression. The significant association between abdominal visceral fat accumulation and SIRT1 gene expression in PBMCs suggests that SIRT1 may be a new therapeutic target for the prevention of disease related to obesity, especially visceral obesity.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfENDOCRINE JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood-
dc.subject.MESHAdiposity/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression-
dc.subject.MESHHealthy Volunteers-
dc.subject.MESHHumans-
dc.subject.MESHIntra-Abdominal Fat/diagnostic imaging-
dc.subject.MESHIntra-Abdominal Fat/metabolism*-
dc.subject.MESHLeukocytes, Mononuclear/metabolism*-
dc.subject.MESHLipid Metabolism-
dc.subject.MESHMale-
dc.subject.MESHPilot Projects-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHRegression Analysis-
dc.subject.MESHSirtuin 1/genetics*-
dc.subject.MESHSirtuin 1/metabolism*-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHWaist Circumference-
dc.titleVisceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: A pilot study-
dc.typeArticle-
dc.contributor.collegeCollege of Nursing (간호대학)-
dc.contributor.departmentDept. of Nursing Environment Systems (임상간호과학과)-
dc.contributor.googleauthorHyangkyu Lee-
dc.contributor.googleauthorSang Hui Chu-
dc.contributor.googleauthorJae Yeo Park-
dc.contributor.googleauthorHyun Ki Park-
dc.contributor.googleauthorJee Aee Im-
dc.contributor.googleauthorJi Won Lee-
dc.identifier.doi10.1507/endocrj.EJ13-0207-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03282-
dc.contributor.localIdA04232-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ00769-
dc.identifier.eissn1348-4540-
dc.identifier.pmid23933590-
dc.subject.keywordSIRT1-
dc.subject.keywordVisceral fat-
dc.subject.keywordObesity-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameLee, Hyang Kyu-
dc.contributor.alternativeNameChoo, Sang Hee-
dc.contributor.affiliatedAuthorLee, Hyang Kyu-
dc.contributor.affiliatedAuthorChoo, Sang Hee-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.rights.accessRightsfree-
dc.citation.volume60-
dc.citation.number11-
dc.citation.startPage1269-
dc.citation.endPage1273-
dc.identifier.bibliographicCitationENDOCRINE JOURNAL, Vol.60(11) : 1269-1273, 2013-
dc.identifier.rimsid34390-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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