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Efficacy of Fractional Microneedle Radiofrequency Device in the Treatment of Primary Axillary Hyperhidrosis: A Pilot Study

Authors
 Kim M  ;  Shin JY  ;  Lee J  ;  Kim JY  ;  Oh SH. 
Citation
 DERMATOLOGY, Vol.227(3) : 243-249, 2013 
Journal Title
 DERMATOLOGY 
ISSN
 1018-8665 
Issue Date
2013
MeSH
Adult ; Apocrine Glands/radiation effects ; Axilla ; Eccrine Glands/radiation effects ; Female ; Humans ; Hyperhidrosis/pathology ; Hyperhidrosis/radiotherapy* ; Hyperthermia, Induced/adverse effects ; Male ; Middle Aged ; Needles ; Patient Satisfaction ; Pilot Projects ; Radio Waves/adverse effects ; Radio Waves/therapeutic use* ; Severity of Illness Index ; Water Loss, Insensible ; Young Adult
Keywords
Adult ; Apocrine Glands/radiation effects ; Axilla ; Eccrine Glands/radiation effects ; Female ; Humans ; Hyperhidrosis/pathology ; Hyperhidrosis/radiotherapy* ; Hyperthermia, Induced/adverse effects ; Male ; Middle Aged ; Needles ; Patient Satisfaction ; Pilot Projects ; Radio Waves/adverse effects ; Radio Waves/therapeutic use* ; Severity of Illness Index ; Water Loss, Insensible ; Young Adult
Abstract
BACKGROUND: Fractional microneedle radiofrequency (FMR) devices deliver energy to the deep dermis through insulated microneedles without destroying the epidermis. These FMR devices have been shown to be effective for the treatment of wrinkles, acne scars and large pores. In this study it was postulated that FMR energy could specifically affect the sweat glands, preserving the skin surface even if sweat glands were seated in the deep dermis. OBJECTIVE: To evaluate the efficacy and safety of FMR for primary axillary hyperhidrosis (PAH) treatment and to conduct a histological analysis before and after treatment. METHODS: Twenty patients with PAH had 2 sessions of bipolar FMR treatment at 4-week intervals. Clinical improvement was evaluated using a Hyperhidrosis Disease Severity Scale (HDSS) and photographs were taken using the starch-iodine test at every visit and 2 months after the last treatment. The amount of sweat reduction was indirectly assessed using a Tewameter™. Skin biopsies were obtained from 3 of the enrolled patients before and after treatment. The satisfaction and adverse reactions of the research participants were recorded at every follow-up visit. RESULTS: HDSS scores decreased significantly from a baseline of 3.3 to 1.5 and 1.8 after the first and second months of posttreatment follow-up sessions, respectively (p < 0.001). In response to a subjective assessment at 1 month after the second treatment, 75% of patients (n = 15) had an HDSS score of 1 or 2, and 70% of patients (n = 14) expressed more than 50% improvement in their sweating. The starch-iodine reaction was also remarkably reduced in 95% of patients (n = 19) after FMR treatment. Histological findings showed a decrease in the number and size of both apocrine and eccrine glands 1 month after the final treatment. Side effects were minimal and included mild discomfort, transient swelling and postinflammatory hyperpigmentation. CONCLUSION: FMR treatment was effective for the treatment of PAH without significant adverse reactions due to direct volumetric heating of the lower dermis.
Full Text
http://www.karger.com/Article/FullText/354602
DOI
10.1159/000354602
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ji Young(김지영)
Shin, Jae Yong(신재용)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88561
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