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Validity of fecal occult blood test in the National Cancer Screening Program, Korea.

Authors
 Aesun Shin  ;  Kui Son Choi  ;  Jae Kwan Jun  ;  Dai Keun Noh  ;  Mina Suh  ;  Kyu-Won Jung  ;  Byung Chang Kim  ;  Jae Hwan Oh  ;  Eun-Cheol Park 
Citation
 PLOS ONE, Vol.8(11) : e79292, 2013 
Journal Title
 PLOS ONE 
Issue Date
2013
MeSH
Aged ; Aged, 80 and over ; Colonic Neoplasms/diagnosis* ; Colonic Neoplasms/metabolism* ; Feces* ; Female ; Humans ; Male ; Mass Screening* ; Middle Aged ; National Health Programs* ; Predictive Value of Tests ; Republic of Korea
Keywords
Aged ; Aged, 80 and over ; Colonic Neoplasms/diagnosis* ; Colonic Neoplasms/metabolism* ; Feces* ; Female ; Humans ; Male ; Mass Screening* ; Middle Aged ; National Health Programs* ; Predictive Value of Tests ; Republic of Korea
Abstract
AIM: The aims of the current study were to assess the validity of the fecal occult blood test (FOBT) in an organized screening setting in Korea and to determine factors associated with FOBT validity, such as screening round, age group, and anatomical location of the cancer. METHODS: Study participants were those who were 50 years and older who received an FOBT through the National Cancer Screening Program between 2004 and 2007. Colorectal cancer diagnoses were ascertained through linkage with the Korean National Cancer Incidence Database. The positivity rate, colorectal cancer detection rate, interval cancer rate, sensitivity, specificity, and positive predictive value of the FOBT were calculated. RESULTS: A total of 2,193,093 tests were included in the analysis. Overall, the sensitivity of the FOBT for colorectal cancer was 59.7% for the first round and 56.1% for the subsequent round. Sensitivity was highest for distal colon cancer (65.9%) in the first round, and for rectal cancer (58.4%) for the subsequent round. The sensitivity and positive predictive value of the FOBT generally improved between 2004 and 2008. CONCLUSIONS: The FOBT showed reasonable validity in an organized screening setting, and the validity of the FOBT varied by screening round, anatomical location, and screening year.
Files in This Item:
T201304072.pdf Download
DOI
10.1371/journal.pone.0079292
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88500
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