Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia

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Citation: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol.36(3) : 84-86, 2013

MeSH: Aged ; Anti-Arrhythmia Agents/adverse effects* ; Arrhythmias, Cardiac/complications ; Bradycardia/chemically induced* ; Bradycardia/complications* ; Female ; Flecainide/adverse effects* ; Humans ; Torsades de Pointes/etiology*

Keywords: Aged ; Anti-Arrhythmia Agents/adverse effects* ; Arrhythmias, Cardiac/complications ; Bradycardia/chemically induced* ; Bradycardia/complications* ; Female ; Flecainide/adverse effects* ; Humans ; Torsades de Pointes/etiology*

Abstract: Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.

Full Text: http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2010.02935.x/abstract

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

Yonsei Authors: Kim, Sung Soon(김성순)
Kim, Han Sang(김한상) https://orcid.org/0000-0002-6504-9927
Park, Jong Seoung(박종성)
Pak, Hui Nam(박희남) https://orcid.org/0000-0002-3256-3620

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