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Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries

Authors
 Moon Jung Kim  ;  Il Kwon Bae  ;  Seok Hoon Jeong  ;  So Hyun Kim  ;  Jae Hoon Song  ;  Jae Young Choi  ;  Sang Sun Yoon  ;  Visanu Thamlikitkul  ;  Po-Ren Hsueh  ;  Rohani Md Yasin  ;  M. K. Lalitha  ;  Kyungwon Lee 
Citation
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol.68 : 2820-2824, 2013 
Journal Title
 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 
ISSN
 0305-7453 
Issue Date
2013
Keywords
IMP-6 ; IMP-26 ; VIM-2 ; VIM-3 ; class 1 integrons
Abstract
OBJECTIVES: To investigate the epidemiological traits of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) clinical isolates collected by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). METHODS: A total of 16 MPPA clinical isolates were collected from six Asian countries in 2000 to 2009 by ANSORP. The MBL gene was detected by PCR amplification. The genetic organization of the class 1 integron carrying the MBL gene cassette was investigated by PCR mapping and sequencing. Southern blotting, repetitive sequence-based PCR and multilocus sequence typing (MLST) experiments were performed to characterize the isolates. RESULTS: PCR and sequencing experiments detected the blaVIM-2 (n = 12), blaVIM-3 (n = 1), blaIMP-6 (n = 2) and blaIMP-26 (n = 1) genes. The MBL genes were located on the chromosome in all isolates except one. Furthermore, all the MBL genes were located in a class 1 integron. All the MPPA isolates from Malaysia, Thailand, Sri Lanka and Korea were identified as sequence type (ST) 235 by MLST. Three VIM-2-producing isolates from India were identified as ST773, and one isolate harbouring VIM-3 from Taiwan was identified as ST298. CONCLUSIONS: P. aeruginosa ST235 might play a role in dissemination of MBL genes in Asian countries.
Full Text
http://jac.oxfordjournals.org/content/68/12/2820.long
DOI
10.1093/jac/dkt269
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Bae, Il Kwon(배일권)
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88457
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