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Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries

 Moon Jung Kim ; Il Kwon Bae ; Kyungwon Lee ; M. K. Lalitha ; Rohani Md Yasin ; Po-Ren Hsueh ; Visanu Thamlikitkul ; Sang Sun Yoon ; Jae Young Choi ; Jae Hoon Song ; So Hyun Kim ; Seok Hoon Jeong 
 Journal of Antimicrobial Chemotherapy, Vol.68 : 2820~2824, 2013 
Journal Title
 Journal of Antimicrobial Chemotherapy 
Issue Date
OBJECTIVES: To investigate the epidemiological traits of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) clinical isolates collected by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). METHODS: A total of 16 MPPA clinical isolates were collected from six Asian countries in 2000 to 2009 by ANSORP. The MBL gene was detected by PCR amplification. The genetic organization of the class 1 integron carrying the MBL gene cassette was investigated by PCR mapping and sequencing. Southern blotting, repetitive sequence-based PCR and multilocus sequence typing (MLST) experiments were performed to characterize the isolates. RESULTS: PCR and sequencing experiments detected the blaVIM-2 (n = 12), blaVIM-3 (n = 1), blaIMP-6 (n = 2) and blaIMP-26 (n = 1) genes. The MBL genes were located on the chromosome in all isolates except one. Furthermore, all the MBL genes were located in a class 1 integron. All the MPPA isolates from Malaysia, Thailand, Sri Lanka and Korea were identified as sequence type (ST) 235 by MLST. Three VIM-2-producing isolates from India were identified as ST773, and one isolate harbouring VIM-3 from Taiwan was identified as ST298. CONCLUSIONS: P. aeruginosa ST235 might play a role in dissemination of MBL genes in Asian countries.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
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