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Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center

Authors
 Jae Yun Lim  ;  Soon Won Hong  ;  Yong Sang Lee  ;  Bup-Woo Kim  ;  Cheong Soo Park  ;  Hang-Seok Chang  ;  Jae Yong Cho 
Citation
 THYROID, Vol.23(11) : 1423-1430, 2013 
Journal Title
 THYROID 
ISSN
 1050-7256 
Issue Date
2013
MeSH
Adenocarcinoma, Follicular/genetics* ; Adenocarcinoma, Follicular/surgery ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma/genetics* ; Carcinoma/surgery ; Carcinoma, Papillary ; DNA Mutational Analysis ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation* ; Polymorphism, Restriction Fragment Length ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics* ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/surgery ; Thyroiditis/metabolism ; Treatment Outcome ; Young Adult
Keywords
Adenocarcinoma, Follicular/genetics* ; Adenocarcinoma, Follicular/surgery ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma/genetics* ; Carcinoma/surgery ; Carcinoma, Papillary ; DNA Mutational Analysis ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Mutation* ; Polymorphism, Restriction Fragment Length ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics* ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/surgery ; Thyroiditis/metabolism ; Treatment Outcome ; Young Adult
Abstract
Background: The BRAF mutation has been shown to be associated with aggressive clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies that analyzed hundreds of patients have not demonstrated any correlation. The objective of this study was to investigate the relationship of the BRAF mutation with clinicopathologic factors in a large group of homogenous PTC patients. Methods: We collected data of PTC patients who received curative resection of the thyroid gland and who had undergone BRAF mutation tests of their thyroid cancer tissue. Minor variant PTCs and mixed-type thyroid cancers were excluded in this analysis. Clinicopathologic characteristics, including age, sex, BRAF mutation, tumor histology, size, extrathyroidal extension, tumor margin, lymph node metastasis, multifocality, stage, and associated thyroid disease, were collected. The relationship of the BRAF mutation with clinicopathologic factors was analyzed in each homogenous histologic PTC. Results: There were 3130 PTC patients who met the criteria, and these patients were divided into three major histologic groups: conventional PTC (n=2947), diffuse sclerosing variant PTC (n=98), and follicular variant PTC (n=85). The BRAF mutation was variably detected in 75.3%, 61%, and 40% of patients, respectively. In conventional PTC cases, the BRAF mutation was significantly associated with large tumor size, extrathyroidal extension, and lymph node metastasis. Coexistent chronic lymphocytic thyroiditis was significantly less prevalent in the BRAF mutant group. Age, sex, and tumor margin status were not significantly correlated with the BRAF status. There was no evidence that any clinicopathologic factors were linked with the BRAF mutation status in diffuse sclerosing and follicular variant PTCs. Conclusions: The BRAF mutation was differentially detected in each histologic subtype of PTC and was strongly correlated with pathologic factors, most strongly with no coexistent chronic lymphocytic thyroiditis, in conventional PTC. The BRAF mutation is suggested to be a poor prognostic marker in conventional PTC, and the BRAF mutational analysis may lead to better management for individual PTC patients.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/thy.2013.0036
DOI
10.1089/thy.2013.0036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Bup Woo(김법우) ORCID logo https://orcid.org/0000-0002-1342-9055
Park, Cheong Soo(박정수)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Lim, Jae Yun(임재윤)
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Cho, Jae Yong(조재용) ORCID logo https://orcid.org/0000-0002-0926-1819
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88440
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