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Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center

DC Field Value Language
dc.contributor.author김법우-
dc.contributor.author박정수-
dc.contributor.author이용상-
dc.contributor.author임재윤-
dc.contributor.author장항석-
dc.contributor.author조재용-
dc.contributor.author홍순원-
dc.date.accessioned2014-12-18T09:34:57Z-
dc.date.available2014-12-18T09:34:57Z-
dc.date.issued2013-
dc.identifier.issn1050-7256-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/88440-
dc.description.abstractBackground: The BRAF mutation has been shown to be associated with aggressive clinicopathologic characteristics of papillary thyroid cancer (PTC). However, several studies that analyzed hundreds of patients have not demonstrated any correlation. The objective of this study was to investigate the relationship of the BRAF mutation with clinicopathologic factors in a large group of homogenous PTC patients. Methods: We collected data of PTC patients who received curative resection of the thyroid gland and who had undergone BRAF mutation tests of their thyroid cancer tissue. Minor variant PTCs and mixed-type thyroid cancers were excluded in this analysis. Clinicopathologic characteristics, including age, sex, BRAF mutation, tumor histology, size, extrathyroidal extension, tumor margin, lymph node metastasis, multifocality, stage, and associated thyroid disease, were collected. The relationship of the BRAF mutation with clinicopathologic factors was analyzed in each homogenous histologic PTC. Results: There were 3130 PTC patients who met the criteria, and these patients were divided into three major histologic groups: conventional PTC (n=2947), diffuse sclerosing variant PTC (n=98), and follicular variant PTC (n=85). The BRAF mutation was variably detected in 75.3%, 61%, and 40% of patients, respectively. In conventional PTC cases, the BRAF mutation was significantly associated with large tumor size, extrathyroidal extension, and lymph node metastasis. Coexistent chronic lymphocytic thyroiditis was significantly less prevalent in the BRAF mutant group. Age, sex, and tumor margin status were not significantly correlated with the BRAF status. There was no evidence that any clinicopathologic factors were linked with the BRAF mutation status in diffuse sclerosing and follicular variant PTCs. Conclusions: The BRAF mutation was differentially detected in each histologic subtype of PTC and was strongly correlated with pathologic factors, most strongly with no coexistent chronic lymphocytic thyroiditis, in conventional PTC. The BRAF mutation is suggested to be a poor prognostic marker in conventional PTC, and the BRAF mutational analysis may lead to better management for individual PTC patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTHYROID-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma, Follicular/genetics*-
dc.subject.MESHAdenocarcinoma, Follicular/surgery-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma/genetics*-
dc.subject.MESHCarcinoma/surgery-
dc.subject.MESHCarcinoma, Papillary-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation*-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics*-
dc.subject.MESHThyroid Neoplasms/genetics*-
dc.subject.MESHThyroid Neoplasms/surgery-
dc.subject.MESHThyroiditis/metabolism-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleClinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorYong Sang Lee-
dc.contributor.googleauthorBup-Woo Kim-
dc.contributor.googleauthorCheong Soo Park-
dc.contributor.googleauthorHang-Seok Chang-
dc.contributor.googleauthorJae Yong Cho-
dc.identifier.doi10.1089/thy.2013.0036-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00491-
dc.contributor.localIdA02978-
dc.contributor.localIdA03398-
dc.contributor.localIdA03488-
dc.contributor.localIdA03899-
dc.contributor.localIdA04411-
dc.contributor.localIdA01646-
dc.relation.journalcodeJ02729-
dc.identifier.eissn1557-9077-
dc.identifier.pmid23496275-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/thy.2013.0036-
dc.subject.keywordAdenocarcinoma, Follicular/genetics*-
dc.subject.keywordAdenocarcinoma, Follicular/surgery-
dc.subject.keywordAdolescent-
dc.subject.keywordAdult-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordCarcinoma/genetics*-
dc.subject.keywordCarcinoma/surgery-
dc.subject.keywordCarcinoma, Papillary-
dc.subject.keywordDNA Mutational Analysis-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordLymphatic Metastasis-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordMutation*-
dc.subject.keywordPolymorphism, Restriction Fragment Length-
dc.subject.keywordPrognosis-
dc.subject.keywordProto-Oncogene Proteins B-raf/genetics*-
dc.subject.keywordThyroid Neoplasms/genetics*-
dc.subject.keywordThyroid Neoplasms/surgery-
dc.subject.keywordThyroiditis/metabolism-
dc.subject.keywordTreatment Outcome-
dc.subject.keywordYoung Adult-
dc.contributor.alternativeNameKim, Bup Woo-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameLee, Yong Sang-
dc.contributor.alternativeNameLim, Jae Yun-
dc.contributor.alternativeNameChang, Hang Seok-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Bup Woo-
dc.contributor.affiliatedAuthorLee, Yong Sang-
dc.contributor.affiliatedAuthorLim, Jae Yun-
dc.contributor.affiliatedAuthorChang, Hang Seok-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number11-
dc.citation.startPage1423-
dc.citation.endPage1430-
dc.identifier.bibliographicCitationTHYROID, Vol.23(11) : 1423-1430, 2013-
dc.identifier.rimsid34036-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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