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The Clinical Measures Associated with C-peptide Decline in Patients with Type 1 Diabetes over 15 Years

 Tae Ho Lee  ;  Ah Reum Kwon  ;  Ye Jin Kim  ;  Hyun Wook Chae  ;  Ho Seong Kim  ;  Duk Hee Kim 
 Journal of Korean Medical Science, Vol.28(9) : 1340-1344, 2013 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Adolescent ; Body Mass Index ; Body Weight ; C-Peptide/blood* ; Child ; Child, Preschool ; Diabetes Complications ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/diagnosis* ; Diabetic Ketoacidosis/epidemiology ; Diabetic Retinopathy/epidemiology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/analysis ; Humans ; Incidence ; Infant ; Male ; Peripheral Nervous System Diseases/epidemiology ; Retrospective Studies
Body Mass Index ; Body Weight ; C-Peptide ; Diabetes Mellitus, Type 1 ; Diabetic Ketoacidosis
This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clinical characteristics were compared between the patients with low and high C-peptide levels, respectively. The average C-peptide level among all patients was significantly reduced five years after diagnosis (P < 0.001). The incidence of diabetic ketoacidosis was significantly lower among the patients with high levels of C-peptide (P = 0.038). The body weight and BMI standard deviation scores (SDS) 15 yr after diagnosis were significantly higher among the patients with low C-peptide levels (weight SDS, P = 0.012; BMI SDS, P = 0.044). In conclusion, C-peptide level was significantly decreased after 5 yr from diagnosis. Type 1 diabetes patients whose beta-cell functions were preserved might have low incidence of diabetic ketoacidosis. The declines of C-peptide level after diagnosis in type 1 diabetes may be associated with changes of body weight and BMI.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Ye Jin(김예진)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
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